The Journal of organic chemistry

Palladium-catalyzed cyclocarbonylation of o-iodoanilines with heterocumulenes: regioselective preparation of 4 (3 H)-quinazolinone derivatives

C Larksarp, H Alper

Index: Larksarp, Chitchamai; Alper, Howard Journal of Organic Chemistry, 2000 , vol. 65, # 9 p. 2773 - 2777

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Citation Number: 123

Abstract

A catalyst system comprising palladium acetate-bidentate phosphine is effective for the cyclocarbonylation of o-iodoanilines with heterocumulenes at 70-100° C for 12-24 h to give the corresponding 4 (3 H)-quinazolinone derivatives in good yields. Utilizing o-iodoaniline with isocyanates, carbodiimides, and ketenimines for the reaction, 2, 4-(1 H, 3 H)- quinazolinediones, 2-amino-4 (3 H)-quinazolinones and 2-alkyl-4 (3 H)-quinazolinones ...

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