Synthesis of α, α-Disubstituted Aryl Amines by Rhodium-Catalyzed Amination of Tertiary Allylic Trichloroacetimidates
JS Arnold, GT Cizio, HM Nguyen
Index: Arnold, Jeffrey S.; Cizio, Gregory T.; Nguyen, Hien M. Organic Letters, 2011 , vol. 13, # 20 p. 5576 - 5579
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Citation Number: 13
Abstract
The rhodium-catalyzed regioselective amination of tertiary allylic trichloroacetimidates with unactivated aromatic amines is a direct and efficient approach to the preparation of α, α- disubstituted allylic aryl amines in good yield and with excellent regioselectivity. This method is applicable to a variety of unactivated primary and secondary amines and allows for the preparation of reverse prenylated indoles in two steps.
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