Formation of phenylpiperazines by a novel alumina supported bis-alkylation
E Mishani, CS Dence, TJ McCarthy, MJ Welch
Index: Mishani, Eyal; Dence, Carmen S.; McCarthy, Timothy J.; Welch, Michael J. Tetrahedron Letters, 1996 , vol. 37, # 3 p. 319 - 322
Full Text: HTML
Citation Number: 52
Abstract
The phenylpiperazine ring which could not be obtained by reacting aniline derivatives with bis (2-bromoethyl)-N-(ethoxycarbonyl) amine (1a) in a wide spectrum of solvents and temperatures was synthesized rapidly on solid support in high yield. By this approach the potent serotonin agonist TFMPP (2) was synthesized in 40 min, in 80% yield. The time scale of this reaction and the simplicity of the work-up match the requirements for short lived ...
Related Articles:
Nickel-catalysed selective N-arylation or N, N′-diarylation of secondary diamines
[Tetrahedron, , vol. 58, # 34 p. 6913 - 6924]
Palladium-catalyzed amination of aryl bromides using temperature-controlled microwave heating
[Wan, Yiqian; Alterman, Mathias; Hallberg, Anders Synthesis, 2002 , # 11 p. 1597 - 1600]
[Brenner, Eric; Schneider, Raphael; Fort, Yves Tetrahedron Letters, 2000 , vol. 41, # 16 p. 2881 - 2884]
Rapid and efficient synthesis of 1-arylpiperazines under microwave irradiation
[Jaisinghani, Harsha G.; Khadilkar, Bhushan M. Tetrahedron Letters, 1997 , vol. 38, # 39 p. 6875 - 6876]
[Tetrahedron Letters, , vol. 39, # 7 p. 617 - 620]