Nitrogen glycosylation reactions involving pyrimidine and purine nucleoside bases with furanoside sugars
LJ Wilson, MW Hager, YA El-Kattan, DC Liotta
Index: Wilson; Hager; El-Kattan; Liotta Synthesis, 1995 , # 12 p. 1465 - 1479
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Citation Number: 62
Abstract
The class of compounds known as 2', 3'-dideoxynucleosides have been used as both anticancer and antiviral drugs. 1 Recently, they have received increased attention due to their activity against the human immunodeficiency virus (HIV). 2 In fact, the emergence of 3'- azido-3'-de-oxythymidine (1, Scheme 1) as an eflective anti-HIV agent has demonstrated the biological importance of nucleosides lacking a 3'-hydroxy functionality. These compounds ...
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