Preparation of 1-(2, 3-dideoxy-. beta.-D-glycero-pent-2-enofuranosyl) thymine (d4T) and 2', 3'-dideoxyadenosine (ddA): general methods for the synthesis of 2', 3'- …
…, DR Tortolani, PR Brodfuehrer, HG Howell…
Index: Mansuri; Starrett Jr.; Wos; Tortolani; Brodfuehrer; Howell; Martin Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4780 - 4785
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Citation Number: 104
Abstract
The 2', 3'-unsaturated thymidine and cytidine analogues 2 and 3, respectively, 2', 3 '- dideoxycytidine (4), and 2', 3'-dideoxyadencwine (5) have been shown to be active in vitro against HIV; therefore, methods for the preparation of these substances are of interest. The conversion of the vicinal diol functionality of ribonucleosides to the 2', 3'-olefic 2', 3'-dideoxy analogues represents one of the most general routes for the preparation of these ...
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