Tetrahedron letters

O-Succinimidyl-1, 3-dimethyl-1, 3-trimethyleneuronium salts as efficient reagents in active ester synthesis

MA Bailén, R Chinchilla, DJ Dodsworth, C Nájera

Index: Bailen, Miguel A; Chinchilla, Rafael; Dodsworth, David J; Najera, Carmen Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1661 - 1664

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Citation Number: 17

Abstract

The new uronium salts O-succinimidyl-1, 3-dimethyl-1, 3-trimethyleneuronium hexafluorophosphate (HSDU) and tetrafluoroborate (TSDU) have been prepared from 1, 3- dimethylpropyleneurea (DMPU) and employed in the synthesis of N-hydroxysuccinimide- derived active esters. High yields were obtained at room temperature in short reaction times and no racemization was observed.

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