Recueil des Travaux Chimiques des Pays??Bas Journal of the Royal Netherlands Chemical Society: General method for the synthesis of 3′, 5′??diesters and 2′?? …
JH van Boom, PMJ Burgers…
Index: Fache, Fabienne; Bethmont, Valerie; Jacquot, Laurent; Lemaire, Marc Recueil des Travaux Chimiques des Pays-Bas-Journal of the Royal Netherlands, 1996 , vol. 115, # 4 p. 231 - 238
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Abstract
Abstract A procedure suitable for the preparation on a large scale of 5′-O-(methoxyacetyl)- 3′-O-propionylribonucleosides (9a-d) from each of the four main ribonucleosides 6a-d has been developed. The usefulness of 9a-d as starting products for the synthesis of crystalline 2′-O-(methoxytetrahydropyranyl)-ribonucleosides (11a-d), which are key intermediates in the synthesis of oligoribonucleotides, has been demonstrated.
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