Tetrahedron Letters

Solvent free, N, N′-carbonyldiimidazole (CDI) mediated amidation

SK Verma, R Ghorpade, A Pratap, MP Kaushik

Index: Verma, Sanjeev K.; Ghorpade, Ramarao; Pratap, Ajay; Kaushik Tetrahedron Letters, 2012 , vol. 53, # 19 p. 2373 - 2376

Full Text: HTML

Citation Number: 21

Abstract

The method involves CDI mediated amidation under solvent-free conditions. The protocol is green, simple, and scalable and has broad structural applicability. The protocol has also been used for BOC protection of amine. The protocol has reduced the time for CDI mediated amidation from 2–4h to 5–10min without the use of any dry organic solvent and nitrogen atmosphere.

Related Articles:

Recueil des Travaux Chimiques des Pays??Bas Journal of the Royal Netherlands Chemical Society: General method for the synthesis of 3′, 5′??diesters and 2′?? …

[Fache, Fabienne; Bethmont, Valerie; Jacquot, Laurent; Lemaire, Marc Recueil des Travaux Chimiques des Pays-Bas-Journal of the Royal Netherlands, 1996 , vol. 115, # 4 p. 231 - 238]

O-Succinimidyl-1, 3-dimethyl-1, 3-trimethyleneuronium salts as efficient reagents in active ester synthesis

[Bailen, Miguel A; Chinchilla, Rafael; Dodsworth, David J; Najera, Carmen Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1661 - 1664]

Zinc oxide (ZnO) as a new, highly efficient, and reusable catalyst for acylation of alcohols, phenols and amines under solvent free conditions

[Hosseini Sarvari, Mona; Sharghi, Hashem Tetrahedron, 2005 , vol. 61, # 46 p. 10903 - 10907]

Direct transacylation of 2, 2, 2-trihaloethyl esters with amines and alcohols using phosphorus (III) reagents for reductive fragmentation and in situ activation

[Hans, Jeremy J.; Driver, Russell W.; Burke, Steven D. Journal of Organic Chemistry, 2000 , vol. 65, # 7 p. 2114 - 2121]

N-Alkylation of carbamates and amides with alcohols catalyzed by a Cp∗ Ir complex

[Fujita, Ken-ichi; Komatsubara, Atsuo; Yamaguchi, Ryohei Tetrahedron, 2009 , vol. 65, # 18 p. 3624 - 3628]

More Articles...