Chemistry–A European Journal

Rh??Catalyzed Enantioselective Conjugate Addition of Arylboronic Acids with a Dynamic Library of Chiral tropos Phosphorus Ligands

C Monti, C Gennari, U Piarulli

Index: Monti, Chiara; Gennari, Cesare; Piarulli, Umberto Chemistry - A European Journal, 2007 , vol. 13, # 5 p. 1547 - 1558

Full Text: HTML

Citation Number: 60

Abstract

Abstract A library of 19 chiral tropos phosphorus ligands, based on a free-to-rotate (tropos) biphenol unit and a chiral P-bonded alcohol (11 phosphites, 1-P (O) 2 O to 11-P (O) 2 O) or secondary amine (8 phosphoramidites, 12-P (O) 2 N to 19-P (O) 2 N), were screened, individually and in combinations of two, in the rhodium-catalyzed asymmetric conjugate addition of arylboronic acids to enones and enoates. High enantioselectivities (up to 99% ...