Enzyme-and ruthenium-catalyzed dynamic kinetic resolution of functionalized cyclic allylic alcohols

R Lihammar, R Millet, JE Bäckvall

Index: Campos, Kevin R.; Klapars, Artis; Kohmura, Yoshinori; Pollard, David; Ishibashi, Hideaki; Kato, Shinji; Takezawa, Akihiro; Waldman, Jacob H.; Wallace, Debra J.; Chen, Cheng-Yi; Yasuda, Nobuyoshi Organic Letters, 2011 , vol. 13, # 5 p. 1004 - 1007

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Citation Number: 17

Abstract

... J. Org. ... rate was higher converting 88% of 1a; however, the product ee was lower (94%) and ketone formation higher than in both toluene and cyclohexane (entry 9). In diisopropyl ether the reaction reached full conversion within 24 h and furnished acetate (R)-2a in 86 ...