Synthesis

A cheap, simple and efficient method for the preparation of symmetrical carboxylic acid anhydrides

F Kazemi, H Sharghi, MA Nasseri

Index: Kazemi, Foad; Sharghi, Hashem; Nasseri, Mohammad Ali Synthesis, 2004 , # 2 p. 205 - 207

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Citation Number: 27

Abstract

Abstract A manipulatively simple and facile one-pot procedure for the synthesis of symmetrical anhydride is reported. Treatment of carboxylic acids with tosyl chloride in K 2 CO 3 media under solvent free conditions gives the corresponding anhydrides in good to excellent yields in a short reaction time via carboxylic sulfonic anhydride as the key intermediate.