5β-Pregnan-3α-ol-20-one-17α,21,21,21-d4

Modify Date: 2025-08-25 20:51:01

5β-Pregnan-3α-ol-20-one-17α,21,21,21-d4 structure	Common Name	5β-Pregnan-3α-ol-20-one-17α,21,21,21-d4
	CAS Number	96737-93-8	Molecular Weight	318.49300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₃₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 5β-Pregnan-3α-ol-20-one-17α,21,21,21-d4

5β-Pregnan-3α-ol-20-one-17α,21,21,21-d4 is the deuterium labeled Pregnanolone. Pregnanolone (Eltanolone), a Progesterone metabolite, is a neurosteroid. Pregnanolone is a GABAA receptor positive allosteric modulator. Pregnanolone has anxiolytic and antidepressant effects[1].

Name	Pregnan-20-one-17,21,21,21-d4, 3-hydroxy-, (3α,5β)-
Synonym	More Synonyms

Description	5β-Pregnan-3α-ol-20-one-17α,21,21,21-d4 is the deuterium labeled Pregnanolone. Pregnanolone (Eltanolone), a Progesterone metabolite, is a neurosteroid. Pregnanolone is a GABAA receptor positive allosteric modulator. Pregnanolone has anxiolytic and antidepressant effects[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Tereza Smejkalova, et al. Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms. Br J Pharmacol. 2021 Oct;178(19):3888-3904.

Molecular Formula	C₂₁H₃₄O₂
Molecular Weight	318.49300
Exact Mass	318.25600
PSA	37.30000
LogP	4.59520

5β-PREGNAN-3α-OL-20-ONE-17α,21,21,21-D4

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5β-Pregnan-3α-ol-20-one-17α,21,21,21-d4

Use of 5β-Pregnan-3α-ol-20-one-17α,21,21,21-d4

Names

Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.