µ-Conotoxin KIIIA

Modify Date: 2025-08-25 18:17:24

µ-Conotoxin KIIIA Structure
µ-Conotoxin KIIIA structure
Common Name µ-Conotoxin KIIIA
CAS Number 884469-67-4 Molecular Weight 1884.16
Density N/A Boiling Point N/A
Molecular Formula C70H106N28O22S6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of µ-Conotoxin KIIIA


μ-Conotoxin KIIIA is an analgesic μ-conotoxin that can be isolated from Conus kinoshitai. μ-Conotoxin KIIIA blocks mammalian neuronal voltage-gated sodium channels (VGSCs) (Nav1.2).μ-Conotoxin KIIIA can be used for research of pain[1][2].

 Names

Name µ-Conotoxin KIIIA

 µ-Conotoxin KIIIA Biological Activity

Description μ-Conotoxin KIIIA is an analgesic μ-conotoxin that can be isolated from Conus kinoshitai. μ-Conotoxin KIIIA blocks mammalian neuronal voltage-gated sodium channels (VGSCs) (Nav1.2).μ-Conotoxin KIIIA can be used for research of pain[1][2].
Related Catalog
Target

NaV1.2 Channel[2]

References

[1]. Khoo KK,et al. Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion. Biochemistry. 2009 Feb 17;48(6):1210-9.  

[2]. Pan X, Li Z, et al. Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA. Science. 2019 Mar 22;363(6433):1309-1313.  

 Chemical & Physical Properties

Molecular Formula C70H106N28O22S6
Molecular Weight 1884.16
InChIKey PRXVBAUMWHTDJW-FMSJUDGMSA-N
SMILES N=C(N)NCCCC1NC(=O)C(CO)NC(=O)C(Cc2cnc[nH]2)NC(=O)C(CC(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C2CSSCC(N)C(=O)NC3CSSCC(NC1=O)C(=O)NC(C(N)=O)CSSCC(NC(=O)C(CC(N)=O)NC3=O)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c3ccccc13)C(=O)N2
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