µ-Conotoxin KIIIA

Names

[ CAS No. ]:
884469-67-4

[ Name ]:
µ-Conotoxin KIIIA

Biological Activity

[Description]:

μ-Conotoxin KIIIA is an analgesic μ-conotoxin that can be isolated from Conus kinoshitai. μ-Conotoxin KIIIA blocks mammalian neuronal voltage-gated sodium channels (VGSCs) (Nav1.2).μ-Conotoxin KIIIA can be used for research of pain[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Inflammation/Immunology

[Target]

NaV1.2 Channel[2]


[References]

[1]. Khoo KK,et al. Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion. Biochemistry. 2009 Feb 17;48(6):1210-9.  

[2]. Pan X, Li Z, et al. Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA. Science. 2019 Mar 22;363(6433):1309-1313.  

Chemical & Physical Properties

[ Molecular Formula ]:
C70H106N28O22S6

[ Molecular Weight ]:
1884.16

Related Compounds

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