hCAIX/XII-IN-8
Modify Date: 2024-01-10 17:08:42
hCAIX/XII-IN-8 structure
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Common Name | hCAIX/XII-IN-8 | ||
|---|---|---|---|---|
| CAS Number | 59994-64-8 | Molecular Weight | 426.28 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H13Cl2N5O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of hCAIX/XII-IN-8hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II[1]. |
| Name | hCAIX/XII-IN-8 |
|---|
| Description | hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II[1]. |
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| Related Catalog | |
| Target |
hCA XII:6.7 nM (Ki) hCA IX:8.5 nM (Ki) hCA II:72.0 nM (Ki) hCA I:5269 nM (Ki) |
| References |
| Molecular Formula | C16H13Cl2N5O3S |
|---|---|
| Molecular Weight | 426.28 |