59994-64-8

59994-64-8 structure

Name: hCAIX/XII-IN-8
Chemical Name: hCAIX/XII-IN-8
CAS Number: 59994-64-8
Molecular Formula: C₁₆H₁₃Cl₂N₅O₃S
Molecular Weight: 426.28
Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
Create Date: 2023-12-21 19:03:00
Modify Date: 2024-01-10 17:08:42
hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II[1].

Name	hCAIX/XII-IN-8

Description	hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase
Target	hCA XII:6.7 nM (Ki) hCA IX:8.5 nM (Ki) hCA II:72.0 nM (Ki) hCA I:5269 nM (Ki)
References	[1]. Akocak S, et al. Potent and selective carbonic anhydrase inhibition activities of pyrazolones bearing benzenesulfonamides. Bioorg Med Chem Lett. 2023 Oct 15;95:129479.

Molecular Formula	C₁₆H₁₃Cl₂N₅O₃S
Molecular Weight	426.28