hCAIX/XII-IN-8
Names
[ CAS No. ]:
59994-64-8
[ Name ]:
hCAIX/XII-IN-8
Biological Activity
[Description]:
hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II[1].
[Related Catalog]:
[Target]
hCA XII:6.7 nM (Ki)
hCA IX:8.5 nM (Ki)
hCA II:72.0 nM (Ki)
hCA I:5269 nM (Ki)
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C16H13Cl2N5O3S
[ Molecular Weight ]:
426.28