hCAIX/XII-IN-8

Names

[ CAS No. ]:
59994-64-8

[ Name ]:
hCAIX/XII-IN-8

Biological Activity

[Description]:

hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

hCA XII:6.7 nM (Ki)

hCA IX:8.5 nM (Ki)

hCA II:72.0 nM (Ki)

hCA I:5269 nM (Ki)


[References]

[1]. Akocak S, et al. Potent and selective carbonic anhydrase inhibition activities of pyrazolones bearing benzenesulfonamides. Bioorg Med Chem Lett. 2023 Oct 15;95:129479.  

Chemical & Physical Properties

[ Molecular Formula ]:
C16H13Cl2N5O3S

[ Molecular Weight ]:
426.28