TP0597850

Modify Date: 2024-04-05 17:51:59

Use of TP0597850

TP0597850 is a selective inhibitor of MMP2 (IC50=0.22 nM). TP0597850 has a long MMP2 dissociation half-life (t1/2=265 min)[1].

Name	TP0597850

Description	TP0597850 is a selective inhibitor of MMP2 (IC50=0.22 nM). TP0597850 has a long MMP2 dissociation half-life (t1/2=265 min)[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	MMP2:0.22 nM (IC50) MMP-12:250 nM (IC50) MMP13:240 nM (IC50)
In Vitro	TP0597850 (化合物 18) 在广谱 pH 值下表现出极高的化学稳定性[1]。 TP0597850 的抑制常数 Ki 值为 0.034 nM[1]。
References	[1]. Takeuchi T, et al. Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide-Pentapeptide Hybrid Scaffold. J Med Chem. 2023 Jan 12;66(1):822-836.

Molecular Formula	C₄₁H₅₇N₉O₁₃S
Molecular Weight	916.01

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