LANA-DNA-IN-1

Modify Date: 2025-08-26 00:36:00

LANA-DNA-IN-1 Structure
LANA-DNA-IN-1 structure
Common Name LANA-DNA-IN-1
CAS Number 2512847-06-0 Molecular Weight 330.34
Density N/A Boiling Point N/A
Molecular Formula C19H14N4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LANA-DNA-IN-1


LANA-DNA-IN-1 is a potent LANA-DNA inhibitor. LANA-DNA-IN-1 has inhibition activity for LBS2, LBS1 and LBS3 with IC50 values of 8 μM, 9μM and 8μM. LANA-DNA-IN-1shows against wild-type LANA with IC50 value of 53 μM. LANA-DNA-IN-1 can be used for the research of infection[1].

 Names

Name LANA-DNA-IN-1

 LANA-DNA-IN-1 Biological Activity

Description LANA-DNA-IN-1 is a potent LANA-DNA inhibitor. LANA-DNA-IN-1 has inhibition activity for LBS2, LBS1 and LBS3 with IC50 values of 8 μM, 9μM and 8μM. LANA-DNA-IN-1shows against wild-type LANA with IC50 value of 53 μM. LANA-DNA-IN-1 can be used for the research of infection[1].
Related Catalog
Target

IC50: 8 μM (LBS2); 9μM LBS1); 8 μM (LBS3); 53 μM (wild-type LANA)[1]

In Vitro LANA-DNA-IN-1 has inhibition activity for LBS2, LBS1 and LBS3 with IC50 values of 8 μM, 9μM and 8μM in FP Assay[1]. LANA-DNA-IN-1 has potent LANA-LBS1-inhibitory with an IC50 values of 53 μM[1]. LANA-DNA-IN-1 (31.25, 62.5, 125 and 250 μM) has potent against wild-type LANA CTD and the oligomerization-deficient LANA DBD mutant[1].
References

[1]. Philine Kirsch, et al. Hit-to-lead optimization of a latency-associated nuclear antigen inhibitor against Kaposi's sarcoma-associated herpesvirus infections. Eur J Med Chem. 2020 Sep 15;202:112525

 Chemical & Physical Properties

Molecular Formula C19H14N4O2
Molecular Weight 330.34
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