PI3Kα/mTOR-IN-1

Modify Date: 2024-01-14 11:58:56

PI3Kα/mTOR-IN-1 structure	Common Name	PI3Kα/mTOR-IN-1
	CAS Number	1013098-90-2	Molecular Weight	310.35
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₈N₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PI3Kα/mTOR-IN-1

PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively.

Name	PI3Kα/mTOR-IN-1

Description	PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively.
Related Catalog	Research Areas >> Cancer
Target	PI3Kα:7 nM (IC50, Cell Assay) PI3Kα:12.5 nM (Ki) mTOR:10.6 nM (Ki)
In Vitro	PI3Kα/mTOR-IN-1 exhibits potent activity against PI3Kα and mTOR, high LipE, good kinase selectivity and robust ADMET properties[1].
In Vivo	PI3Kα/mTOR-IN-1 exhibits low HLM ER, but it is highly cleared in rat liver microsome (RLM) with ER of 0.88. PI3Kα/mTOR-IN-1 exhibits moderate clearance, moderate Vdss, T1/2 of 0.9 h, and good oral bioavailability[1].
References	[1]. Le PT, et al. Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5098-103.

Molecular Formula	C₁₆H₁₈N₆O
Molecular Weight	310.35