PI3Kα/mTOR-IN-1
Modify Date: 2025-08-25 16:19:20
PI3Kα/mTOR-IN-1 structure
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Common Name | PI3Kα/mTOR-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 1013098-90-2 | Molecular Weight | 310.35 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H18N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PI3Kα/mTOR-IN-1PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively. |
| Name | PI3Kα/mTOR-IN-1 |
|---|
| Description | PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively. |
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| Related Catalog | |
| Target |
PI3Kα:7 nM (IC50, Cell Assay) PI3Kα:12.5 nM (Ki) mTOR:10.6 nM (Ki) |
| In Vitro | PI3Kα/mTOR-IN-1 exhibits potent activity against PI3Kα and mTOR, high LipE, good kinase selectivity and robust ADMET properties[1]. |
| In Vivo | PI3Kα/mTOR-IN-1 exhibits low HLM ER, but it is highly cleared in rat liver microsome (RLM) with ER of 0.88. PI3Kα/mTOR-IN-1 exhibits moderate clearance, moderate Vdss, T1/2 of 0.9 h, and good oral bioavailability[1]. |
| References |
| Molecular Formula | C16H18N6O |
|---|---|
| Molecular Weight | 310.35 |
| InChIKey | VMGMCPMGGFUNMP-UHFFFAOYSA-N |
| SMILES | Cc1nc(N)nc2c1cc(-c1cn[nH]c1)c(=O)n2C1CCCC1 |