PI3Kα-IN-6

Modify Date: 2025-09-26 21:06:49

PI3Kα-IN-6 structure	Common Name	PI3Kα-IN-6
	CAS Number	2272894-14-9	Molecular Weight	410.27
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₅IN₂OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PI3Kα-IN-6

PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor. PI3Kα-IN-6 exhibits anticancer potential and no toxicity in normal cells. PI3Kα-IN-6 increases generation of ROS, reduces mitochondrial membrane potential (MMP) and induces apoptosis[1].

Name	PI3Kα-IN-6

Description	PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor. PI3Kα-IN-6 exhibits anticancer potential and no toxicity in normal cells. PI3Kα-IN-6 increases generation of ROS, reduces mitochondrial membrane potential (MMP) and induces apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS
Target	PI3Kα
In Vitro	PI3Kα-IN-6 (Compound 5b) shows cell growth inhibition with IC50 values of 3.5, 8.7, 8.9, 26.5, 89.9, 61.1 and 112.02 against HCT-116, A-549, MiaPaca-2, MCF-7, MDA-MB-231, PC-3 and HEK-293 cells, respectively[1].
References	[1]. Singh D, et al. Synthesis of 3-N-/O-/S-methyl-imidazo[1,2-a] pyridine derivatives for caspase-3 mediated apoptosis induced anticancer activity.

Molecular Formula	C₁₆H₁₅IN₂OS
Molecular Weight	410.27

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PI3Kα-IN-6

Use of PI3Kα-IN-6

Names

PI3Kα-IN-6 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.