Etesevimab

Modify Date: 2024-04-06 13:54:34

Etesevimab Structure
Etesevimab structure
Common Name Etesevimab
CAS Number 2423948-94-9 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Etesevimab


Etesevimab (JS016) is a recombinant neutralizing human IgG1 anti-SARS-CoV-2 monoclonal antibody[1].

 Names

Name Etesevimab

 Etesevimab Biological Activity

Description Etesevimab (JS016) is a recombinant neutralizing human IgG1 anti-SARS-CoV-2 monoclonal antibody[1].
Related Catalog
Target

Kd: 6.45 nM (SARS-CoV-2 spike protein)[1] IC50: 0.32 nM (spike protein attachment to ACE2)[1]

In Vitro Etesevimab (JS016) 与刺突蛋白结合的 Kd 值为 6.45 nM,阻断刺突蛋白附着在人血管紧张素转换酶 2 (ACE2) 受体的 IC50 为 0.32 nM (0.046 μg/mL)[1]。Etesevimab 阻断病毒细胞融合,防止 SARS-CoV-2 入侵人体细胞,并抑制病毒复制[1]。
References

[1]. Wu X, et al. Tolerability, Safety, Pharmacokinetics, and Immunogenicity of a Novel SARS-CoV-2 Neutralizing Antibody, Etesevimab, in Chinese Healthy Adults: a Randomized, Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study. Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0035021.  

 Chemical & Physical Properties

No Any Chemical & Physical Properties
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