Etesevimab

Names

[ CAS No. ]:
2423948-94-9

[ Name ]:
Etesevimab

Biological Activity

[Description]:

Etesevimab (JS016) is a recombinant neutralizing human IgG1 anti-SARS-CoV-2 monoclonal antibody[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

[Target]

Kd: 6.45 nM (SARS-CoV-2 spike protein)[1] IC50: 0.32 nM (spike protein attachment to ACE2)[1]

[In Vitro]

Etesevimab (JS016) 与刺突蛋白结合的 Kd 值为 6.45 nM，阻断刺突蛋白附着在人血管紧张素转换酶 2 (ACE2) 受体的 IC50 为 0.32 nM (0.046 μg/mL)[1]。Etesevimab 阻断病毒细胞融合，防止 SARS-CoV-2 入侵人体细胞，并抑制病毒复制[1]。

[References]

[1]. Wu X, et al. Tolerability, Safety, Pharmacokinetics, and Immunogenicity of a Novel SARS-CoV-2 Neutralizing Antibody, Etesevimab, in Chinese Healthy Adults: a Randomized, Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study. Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0035021.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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