2423948-94-9

2423948-94-9 structure

2423948-94-9 structure

Name: Etesevimab
Chemical Name: Etesevimab
CAS Number: 2423948-94-9
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2023-04-26 15:15:58
Modify Date: 2024-04-06 13:54:34
Etesevimab (JS016) is a recombinant neutralizing human IgG1 anti-SARS-CoV-2 monoclonal antibody[1].

Name	Etesevimab

Description	Etesevimab (JS016) is a recombinant neutralizing human IgG1 anti-SARS-CoV-2 monoclonal antibody[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Target	Kd: 6.45 nM (SARS-CoV-2 spike protein)[1] IC50: 0.32 nM (spike protein attachment to ACE2)[1]
In Vitro	Etesevimab (JS016) 与刺突蛋白结合的 Kd 值为 6.45 nM，阻断刺突蛋白附着在人血管紧张素转换酶 2 (ACE2) 受体的 IC50 为 0.32 nM (0.046 μg/mL)[1]。Etesevimab 阻断病毒细胞融合，防止 SARS-CoV-2 入侵人体细胞，并抑制病毒复制[1]。
References	[1]. Wu X, et al. Tolerability, Safety, Pharmacokinetics, and Immunogenicity of a Novel SARS-CoV-2 Neutralizing Antibody, Etesevimab, in Chinese Healthy Adults: a Randomized, Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study. Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0035021.

No Any Chemical & Physical Properties