c-Kit-IN-2

Modify Date: 2024-01-11 11:30:42

c-Kit-IN-2 structure	Common Name	c-Kit-IN-2
	CAS Number	2121515-37-3	Molecular Weight	519.62
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₉N₉O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of c-Kit-IN-2

c-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively[1].

Name	c-Kit-IN-2

Description	c-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Kit
Target	IC50: 82 nM (c-KIT)[1]
References	[1]. Wu TS, et al. Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants. J Med Chem. 2019 Apr 25;62(8):3940-3957.

Molecular Formula	C₂₅H₂₉N₉O₂S
Molecular Weight	519.62