c-Kit-IN-2

Names

[ CAS No. ]:
2121515-37-3

[ Name ]:
c-Kit-IN-2

Biological Activity

[Description]:

c-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Kit

[Target]

IC50: 82 nM (c-KIT)[1]


[References]

[1]. Wu TS, et al. Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants. J Med Chem. 2019 Apr 25;62(8):3940-3957.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H29N9O2S

[ Molecular Weight ]:
519.62

Related Compounds