BDS-I

Modify Date: 2024-01-24 15:24:35

BDS-I Structure
BDS-I structure
Common Name BDS-I
CAS Number 207621-38-3 Molecular Weight 4708.34
Density N/A Boiling Point N/A
Molecular Formula C210H297N57O56S6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BDS-I


BDS-I known as blood depressing substance, is a marine toxin which can be extracted from Anemonia sulcata. BDS-I is a specific inhibitor of Potassium Channel, targeting to Kv3.4. BDS-I inhibits Aβ1-42-induced enhancement of KV3.4 activity, caspase-3 activation, and abnormal nuclear morphology of NGF-differentiated PC-12 cells. BDS-I reverts the Aβ peptide-induced cell death[1].

 Names

Name BDS-I

 BDS-I Biological Activity

Description BDS-I known as blood depressing substance, is a marine toxin which can be extracted from Anemonia sulcata. BDS-I is a specific inhibitor of Potassium Channel, targeting to Kv3.4. BDS-I inhibits Aβ1-42-induced enhancement of KV3.4 activity, caspase-3 activation, and abnormal nuclear morphology of NGF-differentiated PC-12 cells. BDS-I reverts the Aβ peptide-induced cell death[1].
Related Catalog
Target

Kv3.4[1]

References

[1]. Ciccone R, et al. Synthesis and Pharmacological Evaluation of a Novel Peptide Based on聽Anemonia sulcata聽BDS-I Toxin as a New KV3.4 Inhibitor Exerting a Neuroprotective Effect Against Amyloid-尾 Peptide. Front Chem. 2019 Jul 9;7:479.  

 Chemical & Physical Properties

Molecular Formula C210H297N57O56S6
Molecular Weight 4708.34
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