207621-38-3

207621-38-3 structure

Name: BDS-I
Chemical Name: BDS-I
CAS Number: 207621-38-3
Molecular Formula: C₂₁₀H₂₉₇N₅₇O₅₆S₆
Molecular Weight: 4708.34
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2023-11-11 18:25:39
Modify Date: 2024-01-24 15:24:35
BDS-I known as blood depressing substance, is a marine toxin which can be extracted from Anemonia sulcata. BDS-I is a specific inhibitor of Potassium Channel, targeting to Kv3.4. BDS-I inhibits Aβ1-42-induced enhancement of KV3.4 activity, caspase-3 activation, and abnormal nuclear morphology of NGF-differentiated PC-12 cells. BDS-I reverts the Aβ peptide-induced cell death[1].

Name	BDS-I

Description	BDS-I known as blood depressing substance, is a marine toxin which can be extracted from Anemonia sulcata. BDS-I is a specific inhibitor of Potassium Channel, targeting to Kv3.4. BDS-I inhibits Aβ1-42-induced enhancement of KV3.4 activity, caspase-3 activation, and abnormal nuclear morphology of NGF-differentiated PC-12 cells. BDS-I reverts the Aβ peptide-induced cell death[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	Kv3.4[1]
References	[1]. Ciccone R, et al. Synthesis and Pharmacological Evaluation of a Novel Peptide Based on聽Anemonia sulcata聽BDS-I Toxin as a New KV3.4 Inhibitor Exerting a Neuroprotective Effect Against Amyloid-尾 Peptide. Front Chem. 2019 Jul 9;7:479.

Molecular Formula	C₂₁₀H₂₉₇N₅₇O₅₆S₆
Molecular Weight	4708.34