TBK1/IKKε-IN-1

Modify Date: 2024-01-04 18:05:31

TBK1/IKKε-IN-1 structure	Common Name	TBK1/IKKε-IN-1
	CAS Number	2058264-32-5	Molecular Weight	498.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	N/A	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TBK1/IKKε-IN-1

TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM.

Name	TBK1/IKKε-IN-1

Description	TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM.
Related Catalog	Research Areas >> Cancer
Target	TBK1:100 nM (IC50) IKKε:100 nM (IC50)
In Vitro	IKKε and TBK1 are serine/threonine kinases which are highly homologous to one another and other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognised by the Toll-like receptors 3 and 4 and the RNA helicases RIG-I and MDA-5 and result in activation of the TRIF-TBK1/IKKε-IRF3 signalling cascade, which results in a type I interferon response[1].
References	[1]. Brian A. Sherer, et al. Tbk/ikk inhibitor compounds and uses thereof. US 20160376283 A1.

Molecular Weight	498.53