ON 108600

Modify Date: 2024-02-01 11:35:59

ON 108600 Structure
ON 108600 structure
Common Name ON 108600
CAS Number 1585246-23-6 Molecular Weight 537.39
Density N/A Boiling Point N/A
Molecular Formula C22H14Cl2N2O6S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ON 108600


ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity[1].

 Names

Name ON 108600

 ON 108600 Biological Activity

Description ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity[1].
Related Catalog
Target

DYRK2:0.028 μM (IC50)

DYRK1A:0.016 μM (IC50)

DYRK1B:0.007 μM (IC50)

CK2α2:0.005 μM (IC50)

CK2α1:0.05 μM (IC50)

References

[1]. Katsutoshi Sato, et al. Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease. Nat Commun. 2021 Aug 3;12(1):4671.  

 Chemical & Physical Properties

Molecular Formula C22H14Cl2N2O6S2
Molecular Weight 537.39
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