ON 108600

Names

[ CAS No. ]:
1585246-23-6

[ Name ]:
ON 108600

Biological Activity

[Description]:

ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK
Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase
Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase

[Target]

DYRK2:0.028 μM (IC50)

DYRK1A:0.016 μM (IC50)

DYRK1B:0.007 μM (IC50)

CK2α2:0.005 μM (IC50)

CK2α1:0.05 μM (IC50)


[References]

[1]. Katsutoshi Sato, et al. Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease. Nat Commun. 2021 Aug 3;12(1):4671.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H14Cl2N2O6S2

[ Molecular Weight ]:
537.39

Related Compounds

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