GLP-1(7-37)acetate

Modify Date: 2024-01-02 20:02:13

GLP-1(7-37)acetate structure	Common Name	GLP-1(7-37)acetate
	CAS Number	1450806-98-0	Molecular Weight	3415.72
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅₃H₂₃₂N₄₀O₄₉	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GLP-1(7-37)acetate

GLP-1(7-37) acetate is an intestinal insulinotropic hormone that augments glucose induced insulin secretion[1].

Name	GLP-1(7-37) acetate

Description	GLP-1(7-37) acetate is an intestinal insulinotropic hormone that augments glucose induced insulin secretion[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor
In Vivo	GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats[2]. Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM[2]. Animal Model: Male Sprague-Dawley rats weighing 300 to 350 g with glucose IV at a variablerate for 7 hours to maintain plasma glucose concentration at 11 mM[2]. Dosage: 5 pmol/min/kg. Administration: IV from 1 hour through 7 hours[2]. Result: Produced a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle. Animal Model: Male Sprague-Dawley rats weighing 300 to 350 g with maintained plasma glucose concentration at 11 mM[2]. Dosage: 0.5, 5 or 50 pmol/min/kg. Administration: IV during the second hour of a 2-hour 11-mmol/L hyperglycemic clamp. Result: Produced a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion.
References	[1]. Sarrauste de Menthiere, C. et al. Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. European journal of medicinal chemistry 39, 473-480, doi:10.1016/j.ejmech.2004.02.002 (2004). [2]. Hargrove DM, et al. Glucose-dependent action of glucagon-like peptide-1 (7-37) in vivo during short- or long-term administration. Metabolism. 1995 Sep;44(9):1231-7.

Molecular Formula	C₁₅₃H₂₃₂N₄₀O₄₉
Molecular Weight	3415.72
Storage condition	-20°C