Reticuline

Modify Date: 2025-08-25 20:49:28

Reticuline structure	Common Name	Reticuline
	CAS Number	485-19-8	Molecular Weight	329.390
	Density	1.2±0.1 g/cm3	Boiling Point	504.9±50.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₂₃NO₄	Melting Point	125-126ºC
	MSDS	N/A	Flash Point	259.2±30.1 °C

Use of Reticuline

Reticuline, isolated from Litsea cubeba, shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3[1].

Name	reticuline
Synonym	More Synonyms

Description	Reticuline, isolated from Litsea cubeba, shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> JAK/STAT Signaling >> STAT Research Areas >> Inflammation/Immunology
Target	JAK2 STAT3 NF-κB
References	[1]. Yang X, et al. Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-κB Signaling Pathways. Planta Med. 2018 Jan;84(1):20-25.

Density	1.2±0.1 g/cm3
Boiling Point	504.9±50.0 °C at 760 mmHg
Melting Point	125-126ºC
Molecular Formula	C₁₉H₂₃NO₄
Molecular Weight	329.390
Flash Point	259.2±30.1 °C
Exact Mass	329.162720
PSA	62.16000
LogP	2.09
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.604
InChIKey	BHLYRWXGMIUIHG-HNNXBMFYSA-N
SMILES	COc1ccc(CC2c3cc(O)c(OC)cc3CCN2C)cc1O
Storage condition	-20?C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX5993000

CHEMICAL NAME :: 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-((3-hydroxy-4-methoxyphenyl)meth yl)-6-methoxy-2-methy l-,(S)-

CAS REGISTRY NUMBER :: 485-19-8

BEILSTEIN REFERENCE NO. :: 4299976

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H23-N-O4

MOLECULAR WEIGHT :: 329.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JNPRDF Journal of Natural Products. (Spahr & Glenn Co., 225 E. Spring St., Columbus, OH 43215) V.42- 1979- Volume(issue)/page/year: 42,399,1979

Hazard Codes	Xi

Precursor 7
CAS#:621-59-0 Isovanillin CAS#:2426-87-1 4-(Benzyloxy)-3... CAS#:22231-61-4 2-(4-(Benzyloxy... CAS#:1860-60-2 Benzenemethanol...
CAS#:63909-38-6 4-benzyloxy-3-m... CAS#:55667-12-4 2-(BENZYLOXY)-4... CAS#:121-33-5 Vanillin
DownStream 10
CAS#:3621-36-1 columbamine CAS#:3019-51-0 Isoboldine CAS#:4090-18-0 Salutaridine CAS#:517-56-6 (S)-corytuberine
CAS#:25650-75-3 (9α,13α)-5,6,8,... CAS#:483-45-4 [13aS,(-)]-5,8,... CAS#:605-34-5 discretamine CAS#:56435-41-7 6',7'-dimethoxy...
CAS#:32728-75-9 Cavidine CAS#:524-46-9 [6S,(+)]-6-[(1S...

Name: Selectivity ratio, ratio of IC50 for electric eel AChE to equine serum BChE
Source: ChEMBL
Target: N/A
External Id: CHEMBL3829311

Name: Inhibition of arachidonic acid-induced platelet aggregation in rabbit platelet-rich p...
Source: ChEMBL
Target: Platelet
External Id: CHEMBL987624

Name: Inhibition of equine serum BChE at 100 ug/ml preincubated for 15 mins followed by add...
Source: ChEMBL
Target: Cholinesterase
External Id: CHEMBL3828921

Name: Inhibition of electric eel AChE preincubated for 15 mins followed by addition of acet...
Source: ChEMBL
Target: Acetylcholinesterase
External Id: CHEMBL3828922

Name: Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 as [3H]h...
Source: ChEMBL
Target: Plasmodium falciparum
External Id: CHEMBL991087

Name: Inhibition of equine serum BChE preincubated for 15 mins followed by addition of S-bu...
Source: ChEMBL
Target: Cholinesterase
External Id: CHEMBL3829309

Name: Selectivity ratio, ratio of IC50 for equine serum BChE to electric eel AChE
Source: ChEMBL
Target: N/A
External Id: CHEMBL3829310

Name: Antitubercular activity against Mycobacterium tuberculosis H37Rv by MABA assay
Source: ChEMBL
Target: Mycobacterium tuberculosis
External Id: CHEMBL3387322

Name: Inhibition of adenosine diphosphate-induced platelet aggregation in rabbit platelet-r...
Source: ChEMBL
Target: Platelet
External Id: CHEMBL987621

Name: Vasorelaxant activity against high potassium-induced contraction in Wistar rat thorac...
Source: ChEMBL
Target: Aorta
External Id: CHEMBL990266

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1-(3-Hydroxy-4-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol

Reticuline

1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinol

2-Methyl-7-hydroxy-6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

1-(3-Hydroxy-4-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydro-7-isoquinolinol

Coclanoline

(±)-Reticuline

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Reticuline
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Reticuline
Price: ￥2700.0/5mg
Purity: 97.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

naturewill
China
Product Name: Reticuline
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Bella
Email: 3157321941@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Reticuline
Price: ￥4000.0/5mg
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

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Price: ￥3430/1 mg

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Reticuline

Use of Reticuline

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Reticuline Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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Synthetic Route

Precursor & DownStream

ReticulineBioassay

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.