Entacapone sodium salt
Modify Date: 2026-07-16 14:53:41
Entacapone sodium salt structure
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Common Name | Entacapone sodium salt | ||
|---|---|---|---|---|
| CAS Number | 1047659-02-8 | Molecular Weight | 327.26800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H14N3NaO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Entacapone sodium saltEntacapone is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment. IC50 Value: 151 nMTarget: COMTin vitro: Entacapone inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells.in vivo: Levodopa/carbidopa/entacapone has been shown to improve the pharmacokinetic profile of levodopa and provide superior symptomatic control compared with conventional levodopa/dopa decarboxylase inhibitor therapy. We report four case histories describing clinical experience of using levodopa/carbidopa/entacapone 200/50/200 mg, one of the latest doses of this formulation, in a range of patients with Parkinson's disease. These cases illustrate that levodopa/carbidopa/entacapone 200/50/200 mg provides improvements in symptomatic control.Clinical trial: The combination product carbidopa/levodopa/entacapone (CLE) was approved in 2003 for the treatment of PD patients. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | entacapone, sodium salt |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Entacapone is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment. IC50 Value: 151 nMTarget: COMTin vitro: Entacapone inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells.in vivo: Levodopa/carbidopa/entacapone has been shown to improve the pharmacokinetic profile of levodopa and provide superior symptomatic control compared with conventional levodopa/dopa decarboxylase inhibitor therapy. We report four case histories describing clinical experience of using levodopa/carbidopa/entacapone 200/50/200 mg, one of the latest doses of this formulation, in a range of patients with Parkinson's disease. These cases illustrate that levodopa/carbidopa/entacapone 200/50/200 mg provides improvements in symptomatic control.Clinical trial: The combination product carbidopa/levodopa/entacapone (CLE) was approved in 2003 for the treatment of PD patients. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C14H14N3NaO5 |
|---|---|
| Molecular Weight | 327.26800 |
| Exact Mass | 327.08300 |
| PSA | 133.21000 |
| LogP | 2.74278 |
| InChIKey | UMQUSXKIIWDDTK-OAZHBLANSA-M |
| SMILES | CCN(CC)C(=O)C(C#N)=Cc1cc(O)c([O-])c([N+](=O)[O-])c1.[Na+] |
| Storage condition | 2-8℃ |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Entacapone (sodium salt) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the SMILES notation of entacapone, sodium salt? |
| A: SMILES notation of entacapone, sodium salt is CCN(CC)C(=O)C(C#N)=Cc1cc(O)c([O-])c([N+](=O)[O-])c1.[Na+]. |
| Q: What is the LogP of entacapone, sodium salt? |
| A: LogP of entacapone, sodium salt is 2.74278. |
| Q: What is the molecular weight of entacapone, sodium salt? |
| A: Molecular weight of entacapone, sodium salt is 327.26800. |
| Q: What is the English name of entacapone, sodium salt? |
| A: The English name of entacapone, sodium salt is entacapone, sodium salt. |
| Q: What is the polar surface area (PSA) of entacapone, sodium salt? |
| A: Polar surface area (PSA) of entacapone, sodium salt is 133.21000. |
| Q: What is the InChIKey of entacapone, sodium salt? |
| A: InChIKey of entacapone, sodium salt is UMQUSXKIIWDDTK-OAZHBLANSA-M. |
| Q: What are the storage conditions for entacapone, sodium salt? |
| A: Storage conditions for entacapone, sodium salt: 2-8℃. |
| Q: What is the molecular formula of entacapone, sodium salt? |
| A: Molecular formula of entacapone, sodium salt is C14H14N3NaO5. |
| Q: What is the CAS number of entacapone, sodium salt? |
| A: CAS number of entacapone, sodium salt is 1047659-02-8. |
| Q: What English synonyms does entacapone, sodium salt have? |
| A: English synonyms of entacapone, sodium salt: Entacapone (sodium salt). |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |