D-Luciferin potassium salt
D-Luciferin potassium salt structure
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Common Name | D-Luciferin potassium salt | ||
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| CAS Number | 115144-35-9 | Molecular Weight | 318.41 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H7KN2O3S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of D-Luciferin potassium saltD-Luciferin potassium salt is the substrate of luciferases that catalyze the production of light in bioluminescent insects. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | D-Luciferin potassium salt |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | D-Luciferin potassium salt is the substrate of luciferases that catalyze the production of light in bioluminescent insects. |
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| Related Catalog | |
| In Vitro | D-luciferin is the natural substrate of the enzyme luciferase (Luc), that catalyzes the production of the typical yellowgreen light of fireflies.The present review covers the synthesis of D-luciferin and derivatives or analogues that are substrates or inhibitors of the luciferase from the American firefly Photinus pyralis, the enzyme more frequently used in techniques of in vitro and optical imaging[1]. |
| In Vivo | Bioluminescence imaging (BLI) using the firefly luciferase (Fluc) as a reporter gene and D-luciferin as a substrate is currently the most widely employed technique. The total signal intensity is plotted against the time after D-luciferin injection to generate a time-intensity curve. In addition to the peak signal, the signals at fixed time points (5, 10, 15, and 20 min) after D-luciferin injection are determined as alternatives to the peak signal. The signal in a given time-intensity curve is normalized for the peak signal in the curve to represent the pattern of temporal changes after D-luciferin injection[2]. |
| Animal Admin | Mice[2] In vivo BLI is performed using a cooled charge-coupled device camera system (IVIS Imaging System 100) 3, 5, 7, 10, 12, 14, 19, 21, 24, and 28 days after the inoculation of HCT116-Luc cells. Mice are injected with 75 mg/kg D-luciferin in 100 L of phosphate-buffered saline subcutaneously near the scapula and were placed in the light-tight chamber of the imaging system under isoflurane anesthesia. Beginning 5 min after injection, dorsal luminescent images with an exposure time of 1 s are acquired sequentially at a rate of one image per min until 20 min after D-luciferin injection. Data acquisition is continued until 40 min postinjection on days 3 or 5 and until 25 min on day 7, because of the prolonged time course of light emission. Binning is 4 and the field of view is 15 cm. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C11H7KN2O3S2 |
|---|---|
| Molecular Weight | 318.41 |
| PSA | 136.32000 |
| LogP | 1.38410 |
| InChIKey | UMBKGTQQGYPQBE-OGFXRTJISA-M |
| SMILES | O=C([O-])C1CSC(c2nc3ccc(O)cc3s2)=N1.[K+] |
| Storage condition | ?20°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| HS Code | 2934999090 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Brazilin Isolated from Caesalpinia sappan suppresses nuclear envelope reassembly by inhibiting barrier-to-autointegration factor phosphorylation.
J. Pharmacol. Exp. Ther. 352(1) , 175-84, (2014) To date, many anticancer drugs have been developed by directly or indirectly targeting microtubules, which are involved in cell division. Although this approach has yielded many anticancer drugs, thes... |
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Comparative study of the photoprotolytic reactions of D-luciferin and oxyluciferin.
J. Phys. Chem. A 116 , 7452-7461, (2012) Optical steady-state and time-resolved spectroscopic methods were used to study the photoprotolytic reaction of oxyluciferin, the active bioluminescence chromophore of the firefly's luciferase-catalyz... |
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Label-free phenotypic profiling identified D-luciferin as a GPR35 agonist.
PLoS ONE 7 , e34934, (2012) Fluorescent and luminescent probes are essential to both in vitro molecular assays and in vivo imaging techniques, and have been extensively used to measure biological function. However, little is kno... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-, potassium salt, (4S)- (1:1) |
| MFCD00044928 |
| D-Luciferin potassium salt |
| (S)-2-(6-Hydroxy-2-benzothiazolyl)-2-thiazoline-4-carboxylic acid potassium salt |
| Firefly Luciferin Potassium |
| Potassium (S)-2-(6-hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylate |
| Potassium (4S)-2-(6-hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylate |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the storage conditions for D-Luciferin potassium salt? |
| A: Storage conditions for D-Luciferin potassium salt: ?20°C. |
| Q: What English synonyms does D-Luciferin potassium salt have? |
| A: English synonyms of D-Luciferin potassium salt: 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-, potassium salt, (4S)- (1:1), MFCD00044928, D-Luciferin potassium salt, (S)-2-(6-Hydroxy-2-benzothiazolyl)-2-thiazoline-4-carboxylic acid potassium salt, Firefly Luciferin Potassium, Potassium (S)-2-(6-hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylate, Potassium (4S)-2-(6-hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylate. |
| Q: What is the SMILES notation of D-Luciferin potassium salt? |
| A: SMILES notation of D-Luciferin potassium salt is O=C([O-])C1CSC(c2nc3ccc(O)cc3s2)=N1.[K+]. |
| Q: What is the polar surface area (PSA) of D-Luciferin potassium salt? |
| A: Polar surface area (PSA) of D-Luciferin potassium salt is 136.32000. |
| Q: What is the CAS number of D-Luciferin potassium salt? |
| A: CAS number of D-Luciferin potassium salt is 115144-35-9. |
| Q: What is the InChIKey of D-Luciferin potassium salt? |
| A: InChIKey of D-Luciferin potassium salt is UMBKGTQQGYPQBE-OGFXRTJISA-M. |
| Q: What is the LogP of D-Luciferin potassium salt? |
| A: LogP of D-Luciferin potassium salt is 1.38410. |
| Q: What are the uses of D-Luciferin potassium salt? |
| A: Main uses of D-Luciferin potassium salt: D-Luciferin potassium salt is the substrate of luciferases that catalyze the production of light in bioluminescent insects. |
| Q: What is the molecular weight of D-Luciferin potassium salt? |
| A: Molecular weight of D-Luciferin potassium salt is 318.41. |
| Q: What is the molecular formula of D-Luciferin potassium salt? |
| A: Molecular formula of D-Luciferin potassium salt is C11H7KN2O3S2. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |