meprednisone

Modify Date: 2026-06-29 23:03:48

meprednisone structure	Common Name	meprednisone
	CAS Number	1247-42-3	Molecular Weight	372.455
	Density	1.3±0.1 g/cm3	Boiling Point	574.4±50.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₈O₅	Melting Point	204-206ºC
	MSDS	N/A	Flash Point	315.2±26.6 °C

Use of meprednisone

Meprednisone is a glucocorticoid and a methylated derivative of prednisone.Target: Glucocorticoid ReceptorMeprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL [1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	Meprednisone
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Meprednisone is a glucocorticoid and a methylated derivative of prednisone.Target: Glucocorticoid ReceptorMeprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL [1].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Metabolic Disease
References	[1]. Scheuer, E. and E. Warshaw, Allergy to corticosteroids: update and review of epidemiology, clinical characteristics, and structural cross-reactivity. Am J Contact Dermat, 2003. 14(4): p. 179-87.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.3±0.1 g/cm3
Boiling Point	574.4±50.0 °C at 760 mmHg
Melting Point	204-206ºC
Molecular Formula	C₂₂H₂₈O₅
Molecular Weight	372.455
Flash Point	315.2±26.6 °C
Exact Mass	372.193665
PSA	91.67000
LogP	2.06
Vapour Pressure	0.0±3.6 mmHg at 25°C
Index of Refraction	1.595
InChIKey	PIDANAQULIKBQS-RNUIGHNZSA-N
SMILES	CC1CC2C3CCC4=CC(=O)C=CC4(C)C3C(=O)CC2(C)C1(O)C(=O)CO
Storage condition	2~8°C

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4154090

CHEMICAL NAME :: Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-beta-methyl-

CAS REGISTRY NUMBER :: 1247-42-3

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H28-O5

MOLECULAR WEIGHT :: 372.50

WISWESSER LINE NOTATION :: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 14 mg/kg

SEX/DURATION :: female 16-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 30,1098,1974

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 6250 ug/kg

SEX/DURATION :: female 15-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 11,1042,1977

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

RIDADR	NONH for all modes of transport
HS Code	2937210000

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

Meprednisone Acetate

CAS#:1106-03-2

meprednisone

CAS#:1247-42-3

Learn More

Literature: Journal of the American Chemical Society, , vol. 80, p. 4428 Journal of the American Chemical Society, , vol. 80, p. 4435 Journal of the American Chemical Society, , vol. 82, p. 4012,4025

N/A

CAS#:1253-36-7

meprednisone

CAS#:1247-42-3

Learn More

Literature: Journal of the American Chemical Society, , vol. 80, p. 4428 Journal of the American Chemical Society, , vol. 80, p. 4435 Journal of the American Chemical Society, , vol. 82, p. 4012,4025

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 1
CAS#:1106-03-2 Meprednisone Acetate
DownStream 0

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2937210000

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve...
Source: NCGC
Target: N/A
External Id: OBG420

Total 262, Current Page 1 of 27

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

(16b)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione

16β-Methylprednisone

methylprednisone

deltisonab

(16β)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione

Deltisona B

16b-Methylprednisone

Betapred

Betalone

Betapar

17,21-Dihydroxy-16β-methylpregna-1,4-diene-3,11,20-trione

meprednisone

17,21-Dihydroxy-16b-methylpregna-1,4-diene-3,11,20-trione

Bitanisone

Betanisona

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the SMILES notation of Meprednisone?

A: SMILES notation of Meprednisone is CC1CC2C3CCC4=CC(=O)C=CC4(C)C3C(=O)CC2(C)C1(O)C(=O)CO.

Q: What is the molecular formula of Meprednisone?

A: Molecular formula of Meprednisone is C22H28O5.

Q: What is the InChIKey of Meprednisone?

A: InChIKey of Meprednisone is PIDANAQULIKBQS-RNUIGHNZSA-N.

Q: What is the molecular weight of Meprednisone?

A: Molecular weight of Meprednisone is 372.455.

Q: What is the English name of Meprednisone?

A: The English name of Meprednisone is Meprednisone.

Q: What are the storage conditions for Meprednisone?

A: Storage conditions for Meprednisone: 2~8°C.

Q: What is the melting point of Meprednisone?

A: Melting point of Meprednisone is 204-206ºC.

Q: What is the boiling point of Meprednisone?

A: Boiling point of Meprednisone is 574.4±50.0 °C at 760 mmHg.

Q: What are the upstream materials of Meprednisone?

A: Related upstream materials(CAS) of Meprednisone: 1106-03-2.

Q: What is the polar surface area (PSA) of Meprednisone?

A: Polar surface area (PSA) of Meprednisone is 91.67000.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: meprednisone
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Meprednisone
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Get all suppliers and price by the below link:

meprednisone suppliers

Price: $115/10mg

Reference only. check more meprednisone price

meprednisone

Use of meprednisone

Names

meprednisone Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

meprednisoneBioassay

Synonyms

meprednisone | FAQ

meprednisonefactory

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.