1247-42-3

1247-42-3 structure

Name: meprednisone
Chemical Name: Meprednisone
CAS Number: 1247-42-3
Molecular Formula: C₂₂H₂₈O₅
Molecular Weight: 372.455
Catalog: API Hormone and endocrine-regulating drugs Adrenal corticosteroids
Create Date: 2018-09-15 08:18:27
Modify Date: 2024-01-02 15:46:24
Meprednisone is a glucocorticoid and a methylated derivative of prednisone.Target: Glucocorticoid ReceptorMeprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL [1].

Name	Meprednisone
Synonyms	(16b)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione 16β-Methylprednisone methylprednisone deltisonab (16β)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione Deltisona B 16b-Methylprednisone Betapred Betalone Betapar Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16β)- 17,21-Dihydroxy-16β-methylpregna-1,4-diene-3,11,20-trione meprednisone 17,21-Dihydroxy-16b-methylpregna-1,4-diene-3,11,20-trione Bitanisone Betanisona

Description	Meprednisone is a glucocorticoid and a methylated derivative of prednisone.Target: Glucocorticoid ReceptorMeprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL [1].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Metabolic Disease
References	[1]. Scheuer, E. and E. Warshaw, Allergy to corticosteroids: update and review of epidemiology, clinical characteristics, and structural cross-reactivity. Am J Contact Dermat, 2003. 14(4): p. 179-87.

Density	1.3±0.1 g/cm3
Boiling Point	574.4±50.0 °C at 760 mmHg
Melting Point	204-206ºC
Molecular Formula	C₂₂H₂₈O₅
Molecular Weight	372.455
Flash Point	315.2±26.6 °C
Exact Mass	372.193665
PSA	91.67000
LogP	2.06
Vapour Pressure	0.0±3.6 mmHg at 25°C
Index of Refraction	1.595
Storage condition	2~8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4154090

CHEMICAL NAME :: Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-beta-methyl-

CAS REGISTRY NUMBER :: 1247-42-3

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H28-O5

MOLECULAR WEIGHT :: 372.50

WISWESSER LINE NOTATION :: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 14 mg/kg

SEX/DURATION :: female 16-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 30,1098,1974

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 6250 ug/kg

SEX/DURATION :: female 15-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 11,1042,1977

RIDADR	NONH for all modes of transport
HS Code	2937210000

1106-03-2

1247-42-3

Literature: Journal of the American Chemical Society, , vol. 80, p. 4428 Journal of the American Chemical Society, , vol. 80, p. 4435 Journal of the American Chemical Society, , vol. 82, p. 4012,4025

1253-36-7

1247-42-3

Literature: Journal of the American Chemical Society, , vol. 80, p. 4428 Journal of the American Chemical Society, , vol. 80, p. 4435 Journal of the American Chemical Society, , vol. 82, p. 4012,4025

Precursor 1
1106-03-2
DownStream 0

HS Code	2937210000