Valacyclovir hydrochloride
Valacyclovir hydrochloride structure
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Common Name | Valacyclovir hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 124832-27-5 | Molecular Weight | 360.797 | |
| Density | 1.55g/cm3 | Boiling Point | 588.4ºC at 760 mmHg | |
| Molecular Formula | C13H21ClN6O4 | Melting Point | 170-172ºC | |
| MSDS | Chinese USA | Flash Point | 309.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Valacyclovir hydrochlorideValacyclovir hydrochloride is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B. Target: HSVValacyclovir is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B. VACV uptake was concentration dependent and saturable with a Michaelis-Menten constant and maximum velocity of 1.64 +/- 0.06 mM and 23.34 +/- 0.36 nmol/mg protein/5 min, respectively. A very similar Km value was obtained in hPEPT1/CHO cells and in rat and rabbit tissues and Caco-2 cells, suggesting that hPEPT1 dominates the intestinal transport properties of VACV in vitro . For treatment of a first episode of genital herpes, a large comparative trial has shown that valacyclovir (1 g twice a day) is as effective as acyclovir (200 mg five times a day) when given for 10 days. For treating recurrences, two trials show that valacyclovir is as effective as acyclovir (200 mg five times a day) with a treatment period of 5 days. A daily dose of 1 g of valacyclovir is as effective as 2 g daily. Valacyclovir can be administered once a day. The concentrations of acyclovir in serum and CSF were measured at steady state after 6 days of oral treatment with 1,000 mg of valacyclovir three times a day. EC50 values of PE and AC in 3T3 cells were 0.02 and 0.01 ug/ml, while values in BHK cells were 0.2 and 0.03 ug/ml. Treatment of infected immunosuppressed mice and FA and VA (b.i.d., 5.5 days) reduced the proportion with erythema from 100% to 24% and 38%, and eliminated ear paralysis, ear lesions (vesicles, etc) and death. Virus was absent from ear and brainstem by day 6, but reappeared after discontinuation in mice treated with VA. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Valacyclovir Hydrochloride Hydrate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Valacyclovir hydrochloride is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B. Target: HSVValacyclovir is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B. VACV uptake was concentration dependent and saturable with a Michaelis-Menten constant and maximum velocity of 1.64 +/- 0.06 mM and 23.34 +/- 0.36 nmol/mg protein/5 min, respectively. A very similar Km value was obtained in hPEPT1/CHO cells and in rat and rabbit tissues and Caco-2 cells, suggesting that hPEPT1 dominates the intestinal transport properties of VACV in vitro . For treatment of a first episode of genital herpes, a large comparative trial has shown that valacyclovir (1 g twice a day) is as effective as acyclovir (200 mg five times a day) when given for 10 days. For treating recurrences, two trials show that valacyclovir is as effective as acyclovir (200 mg five times a day) with a treatment period of 5 days. A daily dose of 1 g of valacyclovir is as effective as 2 g daily. Valacyclovir can be administered once a day. The concentrations of acyclovir in serum and CSF were measured at steady state after 6 days of oral treatment with 1,000 mg of valacyclovir three times a day. EC50 values of PE and AC in 3T3 cells were 0.02 and 0.01 ug/ml, while values in BHK cells were 0.2 and 0.03 ug/ml. Treatment of infected immunosuppressed mice and FA and VA (b.i.d., 5.5 days) reduced the proportion with erythema from 100% to 24% and 38%, and eliminated ear paralysis, ear lesions (vesicles, etc) and death. Virus was absent from ear and brainstem by day 6, but reappeared after discontinuation in mice treated with VA. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.55g/cm3 |
|---|---|
| Boiling Point | 588.4ºC at 760 mmHg |
| Melting Point | 170-172ºC |
| Molecular Formula | C13H21ClN6O4 |
| Molecular Weight | 360.797 |
| Flash Point | 309.7ºC |
| Exact Mass | 360.131287 |
| PSA | 151.14000 |
| LogP | 1.28590 |
| Vapour Pressure | 7.95E-14mmHg at 25°C |
| Index of Refraction | 1.673 |
| Storage condition | Refrigerator |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~99%
Valacyclovir hy... CAS#:124832-27-5 |
| Literature: Prasada Raju; Vedantham, Ravindra; Khunt, Mayur D.; Mathad, Vijayavitthal T.; Dubey, Pramod K.; Chakravarthy, Akula Kalyan Asian Journal of Chemistry, 2010 , vol. 22, # 5 p. 4092 - 4098 |
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~%
Valacyclovir hy... CAS#:124832-27-5 |
| Literature: US2007/112193 A1, ; Page/Page column 8 ; |
|
~%
Valacyclovir hy... CAS#:124832-27-5 |
| Literature: Journal of Pharmaceutical Sciences, , vol. 90, # 10 p. 1505 - 1515 |
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~%
Valacyclovir hy... CAS#:124832-27-5 |
| Literature: Journal of Pharmaceutical Sciences, , vol. 90, # 10 p. 1505 - 1515 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 4 | |
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| DownStream 0 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Oral antiviral therapy for prevention of genital herpes outbreaks in immunocompetent and nonpregnant patients.
Cochrane Database Syst. Rev. 8 , CD009036, (2014) Genital herpes is caused by herpes simplex virus 1 (HSV-1) or 2 (HSV-2). Some infected people experience outbreaks of genital herpes, typically, characterized by vesicular and erosive localized painfu... |
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Acute retinal necrosis associated with Epstein-Barr virus: immunohistopathologic confirmation.
JAMA Ophthalmol. 132(7) , 881-2, (2014) Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has ... |
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A pilot study examining the safety and tolerability of valacyclovir in veterans with hepatitis C virus/herpes simplex virus type 2 coinfection.
Am. J. Med. Sci. 348(6) , 455-9, (2014) We performed a pilot study examining the safety and tolerability of valacyclovir in veterans with herpes simplex virus type 2 and hepatitis C virus (HCV) coinfection.We performed a randomized double-b... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester monohydrochloride |
| MFCD01861507 |
| 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl L-valinate hydrochloride |
| L-Valine 2-(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-ylmethoxy)ethyl Ester Hydrochloride Hydrate |
| Valaciclovir |
| 2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl valinate hydrochloride (1:1) |
| 2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl-(2S)-2-amino-3-methylbutanoathydrochlorid |
| 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate hydrochloride |
| Valacyclovir hydrochloride |
| Zelitrex |
| Valaciclovir hydrochloride |
| (2S)-2-amino-3-méthylbutanoate de 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)méthoxy]éthyle chlorhydrate |
| Valaciclovir HCl |
| 256u |
| L-Valine 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester monohydrochloride |
| Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester, hydrochloride (1:1) |
| Valacyclovir hydrochloride hydrate |
| Valacyclovir (hydrochloride) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the melting point of Valacyclovir Hydrochloride Hydrate? |
| A: Melting point of Valacyclovir Hydrochloride Hydrate is 170-172ºC. |
| Q: What is the molecular formula of Valacyclovir Hydrochloride Hydrate? |
| A: Molecular formula of Valacyclovir Hydrochloride Hydrate is C13H21ClN6O4. |
| Q: What are the upstream materials of Valacyclovir Hydrochloride Hydrate? |
| A: Related upstream materials(CAS) of Valacyclovir Hydrochloride Hydrate: 124832-31-1;124832-26-4;59277-89-3;102728-64-3. |
| Q: What is the CAS number of Valacyclovir Hydrochloride Hydrate? |
| A: CAS number of Valacyclovir Hydrochloride Hydrate is 124832-27-5. |
| Q: What is the English name of Valacyclovir Hydrochloride Hydrate? |
| A: The English name of Valacyclovir Hydrochloride Hydrate is Valacyclovir Hydrochloride Hydrate. |
| Q: What are the storage conditions for Valacyclovir Hydrochloride Hydrate? |
| A: Storage conditions for Valacyclovir Hydrochloride Hydrate: Refrigerator. |
| Q: What is the LogP of Valacyclovir Hydrochloride Hydrate? |
| A: LogP of Valacyclovir Hydrochloride Hydrate is 1.28590. |
| Q: What is the molecular weight of Valacyclovir Hydrochloride Hydrate? |
| A: Molecular weight of Valacyclovir Hydrochloride Hydrate is 360.797. |
| Q: What is the polar surface area (PSA) of Valacyclovir Hydrochloride Hydrate? |
| A: Polar surface area (PSA) of Valacyclovir Hydrochloride Hydrate is 151.14000. |
| Q: What is the safety information for Valacyclovir Hydrochloride Hydrate? |
| A: Safety information for Valacyclovir Hydrochloride Hydrate: 26-36. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |