Dorzolamide hydrochloride
Dorzolamide hydrochloride structure
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Common Name | Dorzolamide hydrochloride | ||
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| CAS Number | 130693-82-2 | Molecular Weight | 360.90100 | |
| Density | 1.53 g/cm3 | Boiling Point | 575.8ºC at 760 mmHg | |
| Molecular Formula | C10H17ClN2O4S3 | Melting Point | 283-285ºC | |
| MSDS | N/A | Flash Point | 302ºC | |
Use of Dorzolamide hydrochlorideDorzolamide Hcl(L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor.Target: carbonic anhydrase (CA)Dorzolamide hydrochloride is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent, and acts by decreasing the production of aqueous humour [1]. Glaucoma was induced in the right eye of adult Wistar rats by episcleral venous occlusion. One experimental group was administered dorzolamide hydrochloride 2%-timolol 0.5% combination eye drops, while the other experimental group was administered dorzolamide hydrochloride2% eye drops. Control groups had surgery without drug administration. Drug application was initiated either 2 weeks before surgery (Group A), from the day of surgery (Group B), 2 weeks after surgery (Group C), or 4 weeks after surgery (Group D). RGCs were labeled by intratectal Fluorogold injections and counted from flat-mount preparations, and IOP was measured using Tonopen. Both dorzolamide-timolol combination and dorzolamide hydrochloride, when applied topically, significantly reduced IOP and improved RGC densities in experimental eyes when compared to control eyes. Earlier initiation, as well as longer duration of drug application, resulted in higher RGC densities [2].Clinical indications: Glaucoma; Ocular hypertensionFDA Approved Date: 1995Toxicity: Dizziness, headache, shortness of breath, slow heartbeat, severe asthma, cardiac arrest |
Summary: Dorzolamide hydrochloride, also known as salt酸多佐胺, CAS number 130693-82-2, has a molecular formula of C10H17ClN2O4S3 and a molecular weight of 360.90100. It is a white to gray-white crystalline powder with a melting point of 283-285℃. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | dorzolamide hydrochloride |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Dorzolamide Hcl(L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor.Target: carbonic anhydrase (CA)Dorzolamide hydrochloride is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent, and acts by decreasing the production of aqueous humour [1]. Glaucoma was induced in the right eye of adult Wistar rats by episcleral venous occlusion. One experimental group was administered dorzolamide hydrochloride 2%-timolol 0.5% combination eye drops, while the other experimental group was administered dorzolamide hydrochloride2% eye drops. Control groups had surgery without drug administration. Drug application was initiated either 2 weeks before surgery (Group A), from the day of surgery (Group B), 2 weeks after surgery (Group C), or 4 weeks after surgery (Group D). RGCs were labeled by intratectal Fluorogold injections and counted from flat-mount preparations, and IOP was measured using Tonopen. Both dorzolamide-timolol combination and dorzolamide hydrochloride, when applied topically, significantly reduced IOP and improved RGC densities in experimental eyes when compared to control eyes. Earlier initiation, as well as longer duration of drug application, resulted in higher RGC densities [2].Clinical indications: Glaucoma; Ocular hypertensionFDA Approved Date: 1995Toxicity: Dizziness, headache, shortness of breath, slow heartbeat, severe asthma, cardiac arrest |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.53 g/cm3 |
|---|---|
| Boiling Point | 575.8ºC at 760 mmHg |
| Melting Point | 283-285ºC |
| Molecular Formula | C10H17ClN2O4S3 |
| Molecular Weight | 360.90100 |
| Flash Point | 302ºC |
| Exact Mass | 360.00400 |
| PSA | 151.33000 |
| LogP | 4.66680 |
| Vapour Pressure | 2.93E-13mmHg at 25°C |
| InChIKey | OSRUSFPMRGDLAG-QMGYSKNISA-N |
| SMILES | CCNC1CC(C)S(=O)(=O)c2sc(S(N)(=O)=O)cc21.Cl |
| Storage condition | Refrigerator |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
| HS Code | 2935009090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~97%
Dorzolamide hyd... CAS#:130693-82-2 |
| Literature: RAGACTIVES, S.L. Patent: US2003/220509 A1, 2003 ; Location in patent: Page/Page column 12 ; |
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~99%
Dorzolamide hyd... CAS#:130693-82-2 |
| Literature: CIPLA LIMITED; CURTIS, Philip, Anthony Patent: WO2008/135770 A2, 2008 ; Location in patent: Page/Page column 21-22 ; |
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~%
Dorzolamide hyd... CAS#:130693-82-2 |
| Literature: WO2011/101704 A1, ; |
![(4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno-[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide di-p-toluyl-L-tartate salt structure](https://image.chemsrc.com/caspic/451/1227941-29-8.png)
![6-methyl-4-oxo-5,6-dihydro-4H-thieno[2.3-b]thiopyran-2-sulfonamide-7,7-dioxide structure](https://image.chemsrc.com/caspic/306/935289-26-2.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 2 | |
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| DownStream 0 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Design and in vitro characterization of small unilamellar niosomes as ophthalmic carrier of dorzolamide hydrochloride.
Pharm. Dev. Technol. 19(6) , 748-54, (2014) The objective of this work was to formulate and characterize non-ionic surfactant vesicles (niosomes) as an ocular carrier of dorzolamide hydrochloride (Dorzo); one of the antiglaucoma drugs. Niosomes... |
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Regulation of retinal proteome by topical antiglaucomatous eye drops in an inherited glaucoma rat model.
PLoS ONE 7 , e33593, (2012) Examination of the response of the retinal proteome to elevated intraocular pressure (IOP) and to the pharmacological normalization of IOP is crucial, in order to develop drugs with neuroptorective po... |
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Meta-analysis of α2-adrenergic agonists versus carbonic anhydrase inhibitors as adjunctive therapy.
Curr. Med. Res. Opin. 28(4) , 543-50, (2012) To evaluate the efficacy of α2-adrenergic agonist (AA) brimonidine and topical carbonic anhydrase inhibitors (CAIs) dorzolamide and brinzolamide in reducing intraocular pressure (IOP) when used as adj... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride |
| 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)-, hydrochloride (1:1) |
| Dorzolamide hydrochloride |
| (4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride (1:1) |
| Dorzolamide HCl |
| Dorzolamide |
| (4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno(2,3-b)thiopyran-2-sulfonamide 7,7-dioxide, monohydrochloride |
| (4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamid-7,7-dioxidhydrochlorid |
| 4H-thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)-, monohydrochloride |
| (4S,6S)-4-(éthylamino)-6-méthyl-5,6-dihydro-4H-thiéno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxyde chlorhydrate |
| MFCD00884659 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of dorzolamide hydrochloride? |
| A: CAS number of dorzolamide hydrochloride is 130693-82-2. |
| Q: What is the English name of dorzolamide hydrochloride? |
| A: The English name of dorzolamide hydrochloride is dorzolamide hydrochloride. |
| Q: What is the InChIKey of dorzolamide hydrochloride? |
| A: InChIKey of dorzolamide hydrochloride is OSRUSFPMRGDLAG-QMGYSKNISA-N. |
| Q: What is the molecular weight of dorzolamide hydrochloride? |
| A: Molecular weight of dorzolamide hydrochloride is 360.90100. |
| Q: What is the molecular formula of dorzolamide hydrochloride? |
| A: Molecular formula of dorzolamide hydrochloride is C10H17ClN2O4S3. |
| Q: What are the upstream materials of dorzolamide hydrochloride? |
| A: Related upstream materials(CAS) of dorzolamide hydrochloride: 120279-96-1;1227941-29-8. |
| Q: What is the SMILES notation of dorzolamide hydrochloride? |
| A: SMILES notation of dorzolamide hydrochloride is CCNC1CC(C)S(=O)(=O)c2sc(S(N)(=O)=O)cc21.Cl. |
| Q: What is the boiling point of dorzolamide hydrochloride? |
| A: Boiling point of dorzolamide hydrochloride is 575.8ºC at 760 mmHg. |
| Q: What is the LogP of dorzolamide hydrochloride? |
| A: LogP of dorzolamide hydrochloride is 4.66680. |
| Q: What is the polar surface area (PSA) of dorzolamide hydrochloride? |
| A: Polar surface area (PSA) of dorzolamide hydrochloride is 151.33000. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |