Furagin
Furagin structure
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Common Name | Furagin | ||
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| CAS Number | 1672-88-4 | Molecular Weight | 264.194 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H8N4O5 | Melting Point | 267-270ºC (dec.) | |
| MSDS | N/A | Flash Point | N/A | |
Use of FuraginFuragin, nitrofurantoin analog, is an anti-bacterial agent. Furagin is 2-substituted 5-nitrofuran, chemically and structurally similar to well-known antibacterial compound nitrofurantoin.IC50 Value: Target: Antibacterialin vitro: The furagin concentrations in serum remain several hours above the MIC concentrations of many pathogenic bacteria. Despite the high concentrations in serum, the urine levels of furagin were generally lower than those of nitrofurantoin. The 24 hr recoveries in urine were 8--13% for furagin and about 36% for nitrofurantoin [1].in vivo: A time-independent increase in SCE frequency was found in lymphocytes of children treated with furagin. Total CA frequency did not differ significantly between groups of children with various duration of furagin treatment [2]. Women were randomised into two groups receiving either ciprofloxacin 250mg twice a day for 3 days (n=13) or furagin 100mg three times a day for 7 days (n=14). Median lengths of follow-up were 4 days and 5 days in the ciprofloxacin and furagin groups, respectively [3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione |
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| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Furagin, nitrofurantoin analog, is an anti-bacterial agent. Furagin is 2-substituted 5-nitrofuran, chemically and structurally similar to well-known antibacterial compound nitrofurantoin.IC50 Value: Target: Antibacterialin vitro: The furagin concentrations in serum remain several hours above the MIC concentrations of many pathogenic bacteria. Despite the high concentrations in serum, the urine levels of furagin were generally lower than those of nitrofurantoin. The 24 hr recoveries in urine were 8--13% for furagin and about 36% for nitrofurantoin [1].in vivo: A time-independent increase in SCE frequency was found in lymphocytes of children treated with furagin. Total CA frequency did not differ significantly between groups of children with various duration of furagin treatment [2]. Women were randomised into two groups receiving either ciprofloxacin 250mg twice a day for 3 days (n=13) or furagin 100mg three times a day for 7 days (n=14). Median lengths of follow-up were 4 days and 5 days in the ciprofloxacin and furagin groups, respectively [3]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.6±0.1 g/cm3 |
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| Melting Point | 267-270ºC (dec.) |
| Molecular Formula | C10H8N4O5 |
| Molecular Weight | 264.194 |
| Exact Mass | 264.049469 |
| PSA | 120.73000 |
| LogP | 0.81 |
| Index of Refraction | 1.689 |
| InChIKey | DECBQELQORZLLP-UAIOPKHMSA-N |
| SMILES | O=C1CN(N=CC=Cc2ccc([N+](=O)[O-])o2)C(=O)N1 |
| Storage condition | Refrigerator |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| HS Code | 2934999090 |
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This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Furagin CAS#:1672-88-4 |
| Literature: Yakugaku Zasshi, , vol. 75, p. 117,119, 120 Chem.Abstr., , p. 1782 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 2 | |
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| DownStream 0 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia co...
Source: ChEMBL
Target: Protein cereblon
External Id: CHEMBL4679656
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 1-((3-(5-Nitro-2-furyl)allylidene)amino)-hydantoin |
| Furagin |
| MFCD00431319 |
| 1-{[(1E,2E)-3-(5-Nitro-2-furyl)prop-2-en-1-ylidene]amino}imidazolidine-2,4-dione |
| 1-{(E)-[(2E)-3-(5-Nitro-2-furyl)-2-propen-1-ylidene]amino}-2,4-imidazolidinedione |
| 1-[3-(5-Nitro-[2]furyl)-allylidenamino]-imidazolidin-2,4-dion |
| Furazidin |
| Akritoin |
| Furazidine |
| 1-[3-(5-nitro-[2]furyl)-allylidenamino]-imidazolidine-2,4-dione |
| NF 416 |
| 1-((3-(5-Nitrofuran-2-yl)allylidene)amino)imidazolidine-2,4-dione |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the melting point of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione? |
| A: Melting point of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione is 267-270ºC (dec.). |
| Q: What is the polar surface area (PSA) of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione? |
| A: Polar surface area (PSA) of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione is 120.73000. |
| Q: What is the molecular weight of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione? |
| A: Molecular weight of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione is 264.194. |
| Q: What is the CAS number of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione? |
| A: CAS number of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione is 1672-88-4. |
| Q: What is the LogP of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione? |
| A: LogP of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione is 0.81. |
| Q: What are the storage conditions for 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione? |
| A: Storage conditions for 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione: Refrigerator. |
| Q: What is the molecular formula of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione? |
| A: Molecular formula of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione is C10H8N4O5. |
| Q: What is the English name of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione? |
| A: The English name of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione is 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione. |
| Q: What are the upstream materials of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione? |
| A: Related upstream materials(CAS) of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione: 6301-02-6;1874-22-2. |
| Q: What is the InChIKey of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione? |
| A: InChIKey of 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione is DECBQELQORZLLP-UAIOPKHMSA-N. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |