1672-88-4

1672-88-4 structure

Name: Furagin
Chemical Name: 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione
CAS Number: 1672-88-4
Molecular Formula: C₁₀H₈N₄O₅
Molecular Weight: 264.194
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-09-03 10:21:31
Modify Date: 2024-01-09 01:27:12
Furagin, nitrofurantoin analog, is an anti-bacterial agent. Furagin is 2-substituted 5-nitrofuran, chemically and structurally similar to well-known antibacterial compound nitrofurantoin.IC50 Value: Target: Antibacterialin vitro: The furagin concentrations in serum remain several hours above the MIC concentrations of many pathogenic bacteria. Despite the high concentrations in serum, the urine levels of furagin were generally lower than those of nitrofurantoin. The 24 hr recoveries in urine were 8--13% for furagin and about 36% for nitrofurantoin [1].in vivo: A time-independent increase in SCE frequency was found in lymphocytes of children treated with furagin. Total CA frequency did not differ significantly between groups of children with various duration of furagin treatment [2]. Women were randomised into two groups receiving either ciprofloxacin 250mg twice a day for 3 days (n=13) or furagin 100mg three times a day for 7 days (n=14). Median lengths of follow-up were 4 days and 5 days in the ciprofloxacin and furagin groups, respectively [3].

Name	1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione
Synonyms	1-((3-(5-Nitro-2-furyl)allylidene)amino)-hydantoin Furagin MFCD00431319 1-{[(1E,2E)-3-(5-Nitro-2-furyl)prop-2-en-1-ylidene]amino}imidazolidine-2,4-dione 1-{(E)-[(2E)-3-(5-Nitro-2-furyl)-2-propen-1-ylidene]amino}-2,4-imidazolidinedione 1-[3-(5-Nitro-[2]furyl)-allylidenamino]-imidazolidin-2,4-dion Furazidin 2,4-Imidazolidinedione, 1-[[(1E,2E)-3-(5-nitro-2-furanyl)-2-propen-1-ylidene]amino]- Akritoin Furazidine 1-[3-(5-nitro-[2]furyl)-allylidenamino]-imidazolidine-2,4-dione NF 416 1-((3-(5-Nitrofuran-2-yl)allylidene)amino)imidazolidine-2,4-dione

Description	Furagin, nitrofurantoin analog, is an anti-bacterial agent. Furagin is 2-substituted 5-nitrofuran, chemically and structurally similar to well-known antibacterial compound nitrofurantoin.IC50 Value: Target: Antibacterialin vitro: The furagin concentrations in serum remain several hours above the MIC concentrations of many pathogenic bacteria. Despite the high concentrations in serum, the urine levels of furagin were generally lower than those of nitrofurantoin. The 24 hr recoveries in urine were 8--13% for furagin and about 36% for nitrofurantoin [1].in vivo: A time-independent increase in SCE frequency was found in lymphocytes of children treated with furagin. Total CA frequency did not differ significantly between groups of children with various duration of furagin treatment [2]. Women were randomised into two groups receiving either ciprofloxacin 250mg twice a day for 3 days (n=13) or furagin 100mg three times a day for 7 days (n=14). Median lengths of follow-up were 4 days and 5 days in the ciprofloxacin and furagin groups, respectively [3].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. Mannisto P, et al. Pharmacokinetics of furagin, a new nitrofurantoin congener, on human volunteers. Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):264-70. [2]. Slapsyte G, et al. Cytogenetic analysis of children under long-term antibacterial therapy with nitroheterocyclic compound furagin. Mutat Res. 2001 Apr 5;491(1-2):25-30. [3]. Dybowski B, et al. Ciprofloxacin and furagin in acute cystitis: comparison of early immune and microbiological results. Int J Antimicrob Agents. 2008 Feb;31(2):130-4.

Density	1.6±0.1 g/cm3
Melting Point	267-270ºC (dec.)
Molecular Formula	C₁₀H₈N₄O₅
Molecular Weight	264.194
Exact Mass	264.049469
PSA	120.73000
LogP	0.81
Index of Refraction	1.689
Storage condition	Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MU3870000

CHEMICAL NAME :: Hydantoin, 1-((3-(5-nitro-2-furyl)allylidene)amino)-

CAS REGISTRY NUMBER :: 1672-88-4

BEILSTEIN REFERENCE NO. :: 0307076

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H8-N4-O5

MOLECULAR WEIGHT :: 264.22

WISWESSER LINE NOTATION :: T5OJ BNW E1U2UN- AT5NVMV EHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Phage inhibition capacity

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 3 mg/L

REFERENCE :: CJMIAZ Canadian Journal of Microbiology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1954- Volume(issue)/page/year: 10,932,1964

HS Code	2934999090

6301-02-6

1874-22-2

1672-88-4

Literature: Yakugaku Zasshi, , vol. 75, p. 117,119, 120 Chem.Abstr., , p. 1782

Precursor 2
6301-02-6 1874-22-2
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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