Src Inhibitor-1
Src Inhibitor-1 structure
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Common Name | Src Inhibitor-1 | ||
|---|---|---|---|---|
| CAS Number | 179248-59-0 | Molecular Weight | 373.405 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 528.2±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H19N3O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 273.2±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Src Inhibitor-1Src Inhibitor 1 is a potent and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Src Inhibitor 1 is a potent and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck. |
|---|---|
| Related Catalog | |
| Target |
IC50: 44 nM (Src), 88 nM (Lck)[1] |
| In Vitro | Src-I1 is competitive with both ATP and peptide binding sites of the kinase. The IC50 values are 44 and 88 nM for Src and Lck, respectively[1]. Src-I1, is found to be a potent inhibitor of Src (IC50=0.18 μM), but also inhibited other Src family members, such as Lck, Csk and Yes with similar potency to Src, and RIP2 (IC50=0.026 μM) with even greater potency. In addition, it inhibited CHK2 with similar potency to Src, and Aurora B with slightly lower potency[2]. |
| Kinase Assay | Assays (25.5 μL volume) are carried out robotically at room temperature (21°C) and are linear with respect to time and enzyme concentration under the conditions used. Assays are performed for 30 min using Multidrop Micro reagent dispensers in a 96-well format. The concentration of magnesium acetate in the assays is 10 mM and [γ-33P]ATP (800 c.p.m./pmol) is used at 5, 20 or 50 μM as indicated, in order to be at or below the Kmfor ATP for each enzyme.The assays are initiated with MgATP, stopped by the addition of 5 μL of 0.5 M orthophosphoric acid and spotted on to P81 filter plates using a unifilter harvester. The IC50 values of inhibitors are determined after carrying out assays at ten different concentrations of each compound[2]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 528.2±50.0 °C at 760 mmHg |
| Molecular Formula | C22H19N3O3 |
| Molecular Weight | 373.405 |
| Flash Point | 273.2±30.1 °C |
| Exact Mass | 373.142639 |
| PSA | 65.50000 |
| LogP | 4.90 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.665 |
| InChIKey | DMWVGXGXHPOEPT-UHFFFAOYSA-N |
| SMILES | COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC |
| Storage condition | 2-8°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335-H413 |
| Precautionary Statements | P280-P301 + P312 + P330-P305 + P351 + P338-P337 + P313 |
| RIDADR | UN 3077 9 / PGIII |
This table lists relevant public references with title, journal and publication metadata for this compound.
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PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.
Nat. Commun. 6 , 8100, (2015) Cholesterol biosynthesis is regulated by transcription factors SREBPs and their escort protein Scap. On sterol depletion, Scap/SREBP complex is transported from endoplasmic reticulum (ER) to the Golgi... |
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Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.
J. Hepatol. 62 , 1367-74, (2015) Sustained c-Jun N-terminal kinase (JNK) activation by saturated fatty acids plays a role in lipotoxicity and the pathogenesis of non-alcoholic steatohepatitis (NASH). We have reported that the interac... |
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Dasatinib enhances migration of monocyte-derived dendritic cells by reducing phosphorylation of inhibitory immune receptors Siglec-9 and Siglec-3.
Exp. Hematol. 42(9) , 773-82.e1-3, (2014) The SRC family of kinases (SFKs) is crucial to malignant growth, but also important for signaling in immune cells such as dendritic cells (DCs). These specialized antigen-presenting cells are essentia... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library
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Name: Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV)
Source: NCGC
External Id: APP-Toga-CHIKV-nsp2-p
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Name: Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to contr...
Source: ChEMBL
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-1
External Id: CHEMBL2219380
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Name: Millipore: Percentage of residual kinase activity of NUAK1 at 1uM relative to control...
Source: ChEMBL
Target: NUAK family SNF1-like kinase 1
External Id: CHEMBL2219381
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Name: Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to contr...
Source: ChEMBL
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-1
External Id: CHEMBL2219378
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Name: Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to contro...
Source: ChEMBL
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-1
External Id: CHEMBL2219379
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Name: Millipore: Percentage of residual kinase activity of MAP3K5 at 10uM relative to contr...
Source: ChEMBL
Target: Mitogen-activated protein kinase kinase kinase 5
External Id: CHEMBL2218943
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Name: Millipore: Percentage of residual kinase activity of ABL1 at 1uM relative to control....
Source: ChEMBL
Target: Tyrosine-protein kinase ABL1
External Id: CHEMBL2218944
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Name: Millipore: Percentage of residual kinase activity of NUAK1 at 10uM relative to contro...
Source: ChEMBL
Target: NUAK family SNF1-like kinase 1
External Id: CHEMBL2219382
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Name: Millipore: Percentage of residual kinase activity of MAP3K5 at 1uM relative to contro...
Source: ChEMBL
Target: Mitogen-activated protein kinase kinase kinase 5
External Id: CHEMBL2219383
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 6,7-Dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine |
| Src Kinase Inhikitor |
| Src Kinase Inhibitor I |
| 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine |
| Src-l1 |
| Src Inhibitor-1 |
| KIN001-030 |
| Src Inhibitor 1 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine have? |
| A: English synonyms of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine: 6,7-Dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine, Src Kinase Inhikitor, Src Kinase Inhibitor I, 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine, Src-l1, Src Inhibitor-1, KIN001-030, Src Inhibitor 1. |
| Q: What is the polar surface area (PSA) of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine? |
| A: Polar surface area (PSA) of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine is 65.50000. |
| Q: What is the molecular formula of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine? |
| A: Molecular formula of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine is C22H19N3O3. |
| Q: What is the English name of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine? |
| A: The English name of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine is 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine. |
| Q: What is the InChIKey of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine? |
| A: InChIKey of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine is DMWVGXGXHPOEPT-UHFFFAOYSA-N. |
| Q: What is the boiling point of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine? |
| A: Boiling point of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine is 528.2±50.0 °C at 760 mmHg. |
| Q: What is the CAS number of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine? |
| A: CAS number of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine is 179248-59-0. |
| Q: What is the molecular weight of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine? |
| A: Molecular weight of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine is 373.405. |
| Q: What are the storage conditions for 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine? |
| A: Storage conditions for 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine: 2-8°C. |
| Q: What is the SMILES notation of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine? |
| A: SMILES notation of 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine is COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |