SRPIN340
SRPIN340 structure
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Common Name | SRPIN340 | ||
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| CAS Number | 218156-96-8 | Molecular Weight | 349.350 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 395.9±42.0 °C at 760 mmHg | |
| Molecular Formula | C18H18F3N3O | Melting Point | N/A | |
| MSDS | USA | Flash Point | 193.3±27.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of SRPIN340SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1. |
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| Related Catalog | |
| Target |
Ki: 0.89 μM (SRPK1)[1] |
| In Vitro | SRPIN340 is a serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1. SRPIN340 also inhibits SRPK2, but shows no significant inhibition on other SRPK, such as Clk1 and Clk4. SRPIN340 promotes degradation of SRp75, which is necessary for HIV expression. SRPIN340 suppresses the propagation of Sindbis virus (IC50, 60 μM) as well as severe acute respiratory syndrome virus[1]. SRPIN340 shows inhibitory effect on leukemia cell lines, such as AML HL60, ALL-T Molt4 and Jurkat, with IC50s of 44.7 μM, 92.2 μM and 82.3 μM, respectively[2]. |
| Cell Assay | Leukemic cells (5 × 104 cells/well) and isolated PBMCs (8 × 104 cells/well) are seeded in 96-well plates. Each well contained 100 μL of complete RPMI medium and 100 μL of SRPIN340 solution at different concentrations. The compound is diluted in RPMI medium with 10% fetal bovine serum and 0.4% DMSO (v/v). After 48 h of culture, MTT (5 mg/mL) is added to the wells (3 h, 37°C). The plates are centrifuged at room temperature for 30 min 500 ×g, followed by the removal of the MTT solution and the addition of 100 μL/well of DMSO to solubilize the formazan. Absorbance is measured at 540 nm in a microplate reader. Each experimental procedure is performed in triplicate[2]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 395.9±42.0 °C at 760 mmHg |
| Molecular Formula | C18H18F3N3O |
| Molecular Weight | 349.350 |
| Flash Point | 193.3±27.9 °C |
| Exact Mass | 349.140198 |
| PSA | 45.23000 |
| LogP | 4.15 |
| Appearance of Characters | light yellow solid |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.578 |
| InChIKey | DWFGGOFPIISJIT-UHFFFAOYSA-N |
| SMILES | O=C(Nc1cc(C(F)(F)F)ccc1N1CCCCC1)c1ccncc1 |
| Storage condition | -20℃ |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~85%
SRPIN340 CAS#:218156-96-8 |
| Literature: HAGIWARA, Masatoshi Patent: EP1712242 A1, 2006 ; Location in patent: Page/Page column 18; 31 ; |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 2 | |
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| DownStream 0 | |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma.
Br. J. Cancer 111(3) , 477-85, (2014) Current therapies for metastatic melanoma are targeted either at cancer mutations driving growth (e.g., vemurafenib) or immune-based therapies (e.g., ipilimumab). Tumour progression also requires angi... |
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Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization.
Mol. Vis. 19 , 536-43, (2013) To investigate the applicability of serine/arginine-rich protein kinase (SRPK)-specific inhibitor, SRPIN340, for attenuation of choroidal neovascularization (CNV) formation using a mouse model.Laser p... |
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Dysregulation of splicing proteins in head and neck squamous cell carcinoma.
Cancer Biol. Ther. 17 , 219-29, (2016) Signaling plays an important role in regulating all cellular pathways. Altered signaling is one of the hallmarks of cancers. Phosphoproteomics enables interrogation of kinase mediated signaling pathwa... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 3,4-Dipropoxy-3-cyclobuten-1,2-dion |
| SR protein phosphorylation inhibitor 1 |
| 4-Pyridinecarboxamide (N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl] |
| squaric acid dibutyl ester |
| N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide |
| 1,2-di-n-propoxy-cyclobutenedione |
| di-n-propyl squarate |
| (SRPIN)340 N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide |
| N4-[2-piperidino-5-(trifluoromethyl)phenyl]isonicotinamide |
| 3-Cyclobutene-1,2-dione,3,4-dipropoxy |
| SRPIN-340 |
| SRPIN340 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the uses of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide? |
| A: Main uses of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide: SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1. |
| Q: What are the upstream materials of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide? |
| A: Related upstream materials(CAS) of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide: 1496-40-8;39178-35-3. |
| Q: What are the storage conditions for N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide? |
| A: Storage conditions for N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide: -20℃. |
| Q: What is the English name of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide? |
| A: The English name of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide is N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide. |
| Q: What is the physical appearance of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide? |
| A: N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide appears as light yellow solid. |
| Q: What is the molecular formula of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide? |
| A: Molecular formula of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide is C18H18F3N3O. |
| Q: What is the SMILES notation of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide? |
| A: SMILES notation of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide is O=C(Nc1cc(C(F)(F)F)ccc1N1CCCCC1)c1ccncc1. |
| Q: What is the CAS number of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide? |
| A: CAS number of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide is 218156-96-8. |
| Q: What is the molecular weight of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide? |
| A: Molecular weight of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide is 349.350. |
| Q: What is the InChIKey of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide? |
| A: InChIKey of N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide is DWFGGOFPIISJIT-UHFFFAOYSA-N. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |