Hexadimethrine bromide
Hexadimethrine bromide structure
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Common Name | Hexadimethrine bromide | ||
|---|---|---|---|---|
| CAS Number | 28728-55-4 | Molecular Weight | 404.27 | |
| Density | N/A | Boiling Point | 209.5ºC at 760 mmHg | |
| Molecular Formula | C15H36Br2N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 73.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Hexadimethrine bromideHexadimethrine bromide is a cationic polymer discovered to enhance retroviral transduction. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Sequa-brene |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Hexadimethrine bromide is a cationic polymer discovered to enhance retroviral transduction. |
|---|---|
| Related Catalog | |
| In Vitro | Hexadimethrine bromide inhibits human mesenchymal stem cell proliferation during lentiviral transduction. Hexadimethrine bromide is considered non-toxic at low concentrations, but has been found to negatively affect cell proliferation in some cell types at concentrations greater than 10 µg/mL. Trypsinized cells exposed to Hexadimethrine bromide are visibly larger in size when viewed under the microscope[1]. |
| Cell Assay | Trypsinized cells are washed and resuspended in medium at 2×104 cells/mL with or without rhFGF-2 (final concentration=10 ng/mL, PeproTech) and with or without Hexadimethrine bromide at a final Hexadimethrine bromide concentration of 1, 4, or 8 µg/mL. The different conditions are seeded in 96-well plates at 1×103 cells in 50 µL per well in triplicate and cultured at 37°C, 5% CO2. After 6, 9, or 24 hr, the medium is changed and subsequent medium changes occurred every 3-4 days with 50 µL of ± FGF-2 medium (10 ng/mL). Plates are harvested on day 4, 7, 14, and 21 by removing the medium and placing the plates in the -80°C freezer until the day of analysis. The CyQUANT assay is then performed on the wells[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 209.5ºC at 760 mmHg |
|---|---|
| Molecular Formula | C15H36Br2N2 |
| Molecular Weight | 404.27 |
| Flash Point | 73.9ºC |
| Vapour Pressure | 0.202mmHg at 25°C |
| InChIKey | KZKAYEGOIJEWQB-UHFFFAOYSA-N |
| SMILES | BrCCCBr.CN(C)CCCCCCN(C)C |
| Storage condition | 2-8℃ |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R20/21/22 |
| RIDADR | UN 2811 |
| RTECS | TQ2655000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
This table lists relevant public references with title, journal and publication metadata for this compound.
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NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis.
Cell Death Dis. 6 , e1841, (2015) Dual specificity protein phosphatase 26 (DUSP26) is overexpressed in high-risk neuroblastoma (NB) and contributes to chemoresistance by inhibiting p53 function. In vitro, DUSP26 has also been shown to... |
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Polyomavirus T antigens activate an antiviral state.
Virology 476 , 377-85, (2015) Ectopic expression of Simian Virus 40 (SV40) large T antigen (LT) in mouse embryonic fibroblasts (MEFs) increased levels of mRNAs encoding interferon stimulated genes (ISGs). The mechanism by which T ... |
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Polybrene: Observations on cochlear hair cell necrosis and minimal lentiviral transduction of cochlear hair cells.
Neurosci. Lett. 600 , 164-70, (2015) Polybrene is widely used to enhance viral transduction; however, little is known about the utility thereof, in enhancing lentiviral transduction of cochlear cells. In the present study, we examined th... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Hexadimethrine bromide,Polybrene |
| HEXADIMETHRINE BROMIDE |
| 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide,Polybrene |
| MFCD00133397 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the uses of Sequa-brene? |
| A: Main uses of Sequa-brene: Hexadimethrine bromide is a cationic polymer discovered to enhance retroviral transduction. |
| Q: What is the molecular formula of Sequa-brene? |
| A: Molecular formula of Sequa-brene is C15H36Br2N2. |
| Q: What is the molecular weight of Sequa-brene? |
| A: Molecular weight of Sequa-brene is 404.27. |
| Q: What is the boiling point of Sequa-brene? |
| A: Boiling point of Sequa-brene is 209.5ºC at 760 mmHg. |
| Q: What is the SMILES notation of Sequa-brene? |
| A: SMILES notation of Sequa-brene is BrCCCBr.CN(C)CCCCCCN(C)C. |
| Q: What are the storage conditions for Sequa-brene? |
| A: Storage conditions for Sequa-brene: 2-8℃. |
| Q: What is the English name of Sequa-brene? |
| A: The English name of Sequa-brene is Sequa-brene. |
| Q: What is the CAS number of Sequa-brene? |
| A: CAS number of Sequa-brene is 28728-55-4. |
| Q: What English synonyms does Sequa-brene have? |
| A: English synonyms of Sequa-brene: Hexadimethrine bromide,Polybrene, HEXADIMETHRINE BROMIDE, 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide,Polybrene, MFCD00133397. |
| Q: What is the InChIKey of Sequa-brene? |
| A: InChIKey of Sequa-brene is KZKAYEGOIJEWQB-UHFFFAOYSA-N. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |