Daucosterol
Daucosterol structure
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Common Name | Daucosterol | ||
|---|---|---|---|---|
| CAS Number | 474-58-8 | Molecular Weight | 576.847 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 673.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C35H60O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 361.2±31.5 °C | |
Use of DaucosterolDaucosterol is a natural sterolin. IC50 value:Target:In vitro: In the study of the effects of daucosterol on the survival of cultured cortical neurons after neurons were subjected to oxygen and glucose deprivation and simulated reperfusion (OGD/R)(2), the results showed that post-treatment of daucosterol significantly reduced neuronal loss, as well as apoptotic rate and caspase-3 activity, displaying the neuroprotective activity. We also found that daucosterol increased the expression level of IGF1 protein, diminished the down-regulation of p-AKT(3) and p-GSK-3β(4), thus activating the AKT(5) signal pathway [1]. Cell counting kit-8 (CCK-8) assay showed that daucosterol significantly increased the quantity of viable cells and the effectiveness of daucosterol was similar to that of basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) [2]. Daucosterol inhibits the proliferation of human breast cancer cell line MCF-7 and gastric cancer cell lines MGC803, BGC823 and AGS in a dose-dependent manner. Furthermore, daucosterol inhibits murine hepatoma H22 cell growth in ICR mice. Daucosterol treatment induces intracellular ROS generation and autophagy, but not apoptotic cell death. Treatment with ROS scavenger GSH (reduced glutathione), NAC (N-acetyl-l-cysteine) or autophagy inhibitor 3-Methyladenine (3-MA) counteracted daucosterol-induced autophagy and growth inhibition in BGC823 and MCF-7 cancer cells [3].In vivo: |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Daucosterol |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Daucosterol is a natural sterolin. IC50 value:Target:In vitro: In the study of the effects of daucosterol on the survival of cultured cortical neurons after neurons were subjected to oxygen and glucose deprivation and simulated reperfusion (OGD/R)(2), the results showed that post-treatment of daucosterol significantly reduced neuronal loss, as well as apoptotic rate and caspase-3 activity, displaying the neuroprotective activity. We also found that daucosterol increased the expression level of IGF1 protein, diminished the down-regulation of p-AKT(3) and p-GSK-3β(4), thus activating the AKT(5) signal pathway [1]. Cell counting kit-8 (CCK-8) assay showed that daucosterol significantly increased the quantity of viable cells and the effectiveness of daucosterol was similar to that of basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) [2]. Daucosterol inhibits the proliferation of human breast cancer cell line MCF-7 and gastric cancer cell lines MGC803, BGC823 and AGS in a dose-dependent manner. Furthermore, daucosterol inhibits murine hepatoma H22 cell growth in ICR mice. Daucosterol treatment induces intracellular ROS generation and autophagy, but not apoptotic cell death. Treatment with ROS scavenger GSH (reduced glutathione), NAC (N-acetyl-l-cysteine) or autophagy inhibitor 3-Methyladenine (3-MA) counteracted daucosterol-induced autophagy and growth inhibition in BGC823 and MCF-7 cancer cells [3].In vivo: |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 673.6±55.0 °C at 760 mmHg |
| Molecular Formula | C35H60O6 |
| Molecular Weight | 576.847 |
| Flash Point | 361.2±31.5 °C |
| Exact Mass | 576.438965 |
| PSA | 99.38000 |
| LogP | 8.78 |
| Vapour Pressure | 0.0±4.7 mmHg at 25°C |
| Index of Refraction | 1.554 |
| InChIKey | NPJICTMALKLTFW-OFUAXYCQSA-N |
| SMILES | CCC(CCC(C)C1CCC2C3CC=C4CC(OC5OC(CO)C(O)C(O)C5O)CCC4(C)C3CCC12C)C(C)C |
| Storage condition | 2-8°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Safety Phrases | 24/25 |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 29389090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 7 | |
|---|---|
| DownStream 5 | |
![3-[(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)oxy]-sitosterol Structure](https://image.chemsrc.com/caspic/093/137909-13-8.png)
CAS#:137909-13-8
CAS#:83-46-5
CAS#:572-09-8
CAS#:4291-69-4
CAS#:74808-09-6
CAS#:53657-29-7
CAS#:18749-71-8
CAS#:2280-44-6
CAS#:50-99-7
CAS#:1139-97-5This table lists relevant public references with title, journal and publication metadata for this compound.
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[Chemical constituents contained in seeds of Notopterygium franchetii].
Zhongguo Zhong Yao Za Zhi 37(7) , 941-5, (2012) To study the chemical constituents from the seeds of Notopterygium franchetii.Ethanol extracts of seeds N. franchetii were separated and purified by such methods as normal and reversed phase column ch... |
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[Study on the chemical constituets in ethyl acetante extraction from semen litchi].
Zhong Yao Cai 35(1) , 64-6, (2012) To study the chemical constituents in ethyl acetate extraction of Semen Litchi.The compounds were isolated and purified by column chromatography on silica gel and Sephadex LH-20 coupled with preparati... |
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[Chemical constituents from stems of Dysoxylum laxiracemosum].
Zhongguo Zhong Yao Za Zhi 37(9) , 1237-40, (2012) Twelve compounds were separated from stems of Dysoxylum laxiracemosum and their structures were identified by spectrum analysis as shoreic acid (1), cabraleahydroxylactone (2), cabralealactone (3), ci... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| β-D-Glucopyranoside, (3β)-stigmast-5-en-3-yl |
| Daucosterin |
| lyoniside |
| Coriandrinol |
| (3b)-Stigmast-5-en-3-yl b-D-Glucopyranoside |
| Sitogluside |
| β-Sitosterol β-D-glucoside |
| β-sitosterol-D-glucoside |
| b-Daucosterol |
| b-Sitosteryl glucoside |
| Alexandrin |
| Eleutheroside A |
| β-sitosterol 3-O-β-D-glucopyranoside |
| 1513DMIa |
| Sterolin |
| β-sitosteryl-β-D-glucopyranoside |
| 3b-(b-D-glucopyranosyloxy)stigmast-5-ene |
| Doursterol |
| (3β)-Stigmast-5-en-3-yl β-D-glucopyranoside |
| 3β-(β-D-Glucopyranosyloxy)stigmast-5-ene |
| BSSG |
| β-Sitosteryl glucoside |
| 3-β-D-glucosylsitosterol |
| 3-β-(β-D-Glucopyranosyloxy)stigmast-5-ene |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of Daucosterol? |
| A: CAS number of Daucosterol is 474-58-8. |
| Q: What are the storage conditions for Daucosterol? |
| A: Storage conditions for Daucosterol: 2-8°C. |
| Q: What is the molecular formula of Daucosterol? |
| A: Molecular formula of Daucosterol is C35H60O6. |
| Q: What are the downstream products of Daucosterol? |
| A: Related downstream products(CAS) of Daucosterol: 18749-71-8;83-46-5;2280-44-6;50-99-7;1139-97-5. |
| Q: What is the LogP of Daucosterol? |
| A: LogP of Daucosterol is 8.78. |
| Q: What is the boiling point of Daucosterol? |
| A: Boiling point of Daucosterol is 673.6±55.0 °C at 760 mmHg. |
| Q: What are the upstream materials of Daucosterol? |
| A: Related upstream materials(CAS) of Daucosterol: 137909-13-8;83-46-5;572-09-8;4291-69-4;74808-09-6;53657-29-7;18749-71-8. |
| Q: What is the molecular weight of Daucosterol? |
| A: Molecular weight of Daucosterol is 576.847. |
| Q: What is the English name of Daucosterol? |
| A: The English name of Daucosterol is Daucosterol. |
| Q: What is the InChIKey of Daucosterol? |
| A: InChIKey of Daucosterol is NPJICTMALKLTFW-OFUAXYCQSA-N. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |