MANGANESE, CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KN)METHYLIDYNE]]BIS[PHENOLATO-KO]](2-)]-, (SP-5-13)

Modify Date: 2026-07-01 16:40:19

MANGANESE, CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KN)METHYLIDYNE]]BIS[PHENOLATO-KO]](2-)]-, (SP-5-13) structure	Common Name	MANGANESE, CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KN)METHYLIDYNE]]BIS[PHENOLATO-KO]](2-)]-, (SP-5-13)
	CAS Number	53177-12-1	Molecular Weight	356.686
	Density	N/A	Boiling Point	448.8ºC at 760mmHg
	Molecular Formula	C₁₆H₁₄ClMnN₂O₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	294.1ºC

Use of MANGANESE, CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KN)METHYLIDYNE]]BIS[PHENOLATO-KO]](2-)]-, (SP-5-13)

Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vitro	Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation[2].
In Vivo	Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant[3]. Animal Model: Wild-type (WT) and harlequin (Hq) B6CBA male and female mice[3] Dosage: 25 mg/kg/day Administration: I.p. 3 times a week for 4 weeks Result: Prevented myocardial oxidant damage provoked by biomechanical stress. Improved survival following biomechanical stress. Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.
References	[1]. Gonzalez PK, et, al. EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine. J Pharmacol Exp Ther. 1995 Nov;275(2):798-806. [2]. Bruce AJ, et, al. beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2312-6. [3]. Empel VPM, et, al. EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. J Am Coll Cardiol. 2006 Aug 15;48(4):824-32.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Boiling Point	448.8ºC at 760mmHg
Molecular Formula	C₁₆H₁₄ClMnN₂O₂
Molecular Weight	356.686
Flash Point	294.1ºC
Exact Mass	356.012421
PSA	70.84000
LogP	0.51620
InChIKey	HBQGFROGWOHBAG-UHFFFAOYSA-K
SMILES	[Cl-].[Mn+3].[O-]c1ccccc1C=NCCN=Cc1ccccc1[O-]
Storage condition	-20°C

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

MSDS(Chinese)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

RIDADR	NONH for all modes of transport

This table lists relevant public references with title, journal and publication metadata for this compound.

Asymmetric epoxidation of unfunctionalized alkenes catalyzed by sugar moiety-modified chiral salen-Mn(III) complexes.

Carbohydr. Res. 344(1) , 61-6, (2009)

Several chiral Schiff-base ligands with sugar moieties at C-3 (3') or C-5 (5') of salicylaldehyde were synthesized from reaction of salicylaldehyde derivatives with diamine. These ligands coordinated ...

Fluorimetric study of the pro-oxidant activity of EUK8 in the presence of hydrogen peroxide.

Biometals 21(4) , 425-32, (2008)

The catalase mimetic complex Mn(III)-salen chloride (EUK8) was found to be pro-oxidant under low hydrogen peroxide concentrations. The increase in the fluorescence rate of the probe 1,2,3-dihydrorhoda...

Role of superoxide dismutase enzymes and ascorbate in protection of nitrergic relaxation against superoxide anions in mouse duodenum.

Acta Pharmacol. Sin. 29(6) , 687-97, (2008)

The aim of this study was to investigate whether superoxide dismutase (SOD) enzymes and ascorbate play a role in the protection of the nitrergic relaxation against superoxide anion inhibition in the m...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

euk-8

1,2-bis(salicylideneamino)ethane manganese(III) chloride

2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate

Manganese,chloro((2,2'-(1,2-ethanediylbis(nitrilomethylidyne))bis(phenolato))(2-)-N,N',O,O')-,(SP-5-13)

Mn(salen)Cl

chloro-[N,N'-bis(salicylidene)ethylenediaminato]manganese(III)

N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II)

[manganese(III)Cl(N,N'-bis(salicylidene) ethylenediamine)]

Manganese(3+) chloride 2,2'-{1,2-ethanediylbis[nitrilo(E)methylylidene]}diphenolate (1:1:1)

[2,2'-[ethane-1,2-diil-bis(nitrilo-methylidyne)]diphenolato]-manganese(III)-chloride

Phenol, 2,2'-[1,2-ethanediylbis[nitrilo(E)methylidyne]]bis-, manganese(3+) salt, hydrochloride (1:1:1)

N,N'-Bis(salicylideneamino)ethane-manganese(II)

(N,N'-ethylenebis(salicylideneaminato))MnCl

Salen-manganese complex

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride?

A: CAS number of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride is 53177-12-1.

Q: What are the uses of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride?

A: Main uses of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride: Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2].

Q: What is the molecular formula of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride?

A: Molecular formula of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride is C16H14ClMnN2O2.

Q: What is the English name of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride?

A: The English name of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride is manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride.

Q: What is the polar surface area (PSA) of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride?

A: Polar surface area (PSA) of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride is 70.84000.

Q: What is the SMILES notation of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride?

A: SMILES notation of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride is [Cl-].[Mn+3].[O-]c1ccccc1C=NCCN=Cc1ccccc1[O-].

Q: What are the storage conditions for manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride?

A: Storage conditions for manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride: -20°C.

Q: What is the InChIKey of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride?

A: InChIKey of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride is HBQGFROGWOHBAG-UHFFFAOYSA-K.

Q: What is the LogP of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride?

A: LogP of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride is 0.51620.

Q: What is the molecular weight of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride?

A: Molecular weight of manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride is 356.686.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

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MANGANESE, CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KN)METHYLIDYNE]]BIS[PHENOLATO-KO]](2-)]-, (SP-5-13)

Use of MANGANESE, CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KN)METHYLIDYNE]]BIS[PHENOLATO-KO]](2-)]-, (SP-5-13)

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