MANGANESE, CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KN)METHYLIDYNE]]BIS[PHENOLATO-KO]](2-)]-, (SP-5-13)-

Names

[ Name ]:
MANGANESE, CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KN)METHYLIDYNE]]BIS[PHENOLATO-KO]](2-)]-, (SP-5-13)-

[Synonym ]:
euk-8
1,2-bis(salicylideneamino)ethane manganese(III) chloride
2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate
Manganese,chloro((2,2'-(1,2-ethanediylbis(nitrilomethylidyne))bis(phenolato))(2-)-N,N',O,O')-,(SP-5-13)
Mn(salen)Cl
chloro-[N,N'-bis(salicylidene)ethylenediaminato]manganese(III)
N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II)
[manganese(III)Cl(N,N'-bis(salicylidene) ethylenediamine)]
Manganese(3+) chloride 2,2'-{1,2-ethanediylbis[nitrilo(E)methylylidene]}diphenolate (1:1:1)
[2,2'-[ethane-1,2-diil-bis(nitrilo-methylidyne)]diphenolato]-manganese(III)-chloride
Phenol, 2,2'-[1,2-ethanediylbis[nitrilo(E)methylidyne]]bis-, manganese(3+) salt, hydrochloride (1:1:1)
N,N'-Bis(salicylideneamino)ethane-manganese(II)
(N,N'-ethylenebis(salicylideneaminato))MnCl
Salen-manganese complex

Biological Activity

[Description]:

Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[In Vitro]

Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation[2].

[In Vivo]

Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant[3]. Animal Model: Wild-type (WT) and harlequin (Hq) B6CBA male and female mice[3] Dosage: 25 mg/kg/day Administration: I.p. 3 times a week for 4 weeks Result: Prevented myocardial oxidant damage provoked by biomechanical stress. Improved survival following biomechanical stress. Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.

[References]

[1]. Gonzalez PK, et, al. EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine. J Pharmacol Exp Ther. 1995 Nov;275(2):798-806.

[2]. Bruce AJ, et, al. beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2312-6.

[3]. Empel VPM, et, al. EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. J Am Coll Cardiol. 2006 Aug 15;48(4):824-32.

Chemical & Physical Properties

[ Boiling Point ]:
448.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₄ClMnN₂O₂

[ Molecular Weight ]:
356.686

[ Flash Point ]:
294.1ºC

[ Exact Mass ]:
356.012421

[ PSA ]:
70.84000

[ LogP ]:
0.51620

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Asymmetric epoxidation of unfunctionalized alkenes catalyzed by sugar moiety-modified chiral salen-Mn(III) complexes.

Carbohydr. Res. 344(1) , 61-6, (2009)

Several chiral Schiff-base ligands with sugar moieties at C-3 (3') or C-5 (5') of salicylaldehyde were synthesized from reaction of salicylaldehyde derivatives with diamine. These ligands coordinated ...

Fluorimetric study of the pro-oxidant activity of EUK8 in the presence of hydrogen peroxide.

Biometals 21(4) , 425-32, (2008)

The catalase mimetic complex Mn(III)-salen chloride (EUK8) was found to be pro-oxidant under low hydrogen peroxide concentrations. The increase in the fluorescence rate of the probe 1,2,3-dihydrorhoda...

Role of superoxide dismutase enzymes and ascorbate in protection of nitrergic relaxation against superoxide anions in mouse duodenum.

Acta Pharmacol. Sin. 29(6) , 687-97, (2008)

The aim of this study was to investigate whether superoxide dismutase (SOD) enzymes and ascorbate play a role in the protection of the nitrergic relaxation against superoxide anion inhibition in the m...