1,2,3,4-Tetrahydroquinoline-6-carboxylic acid

Modify Date: 2026-07-02 01:31:25

1,2,3,4-Tetrahydroquinoline-6-carboxylic acid Structure
1,2,3,4-Tetrahydroquinoline-6-carboxylic acid structure
Common Name 1,2,3,4-Tetrahydroquinoline-6-carboxylic acid
CAS Number 5382-49-0 Molecular Weight 177.200
Density 1.2±0.1 g/cm3 Boiling Point 382.6±31.0 °C at 760 mmHg
Molecular Formula C10H11NO2 Melting Point 168ºC
MSDS Chinese USA Flash Point 185.2±24.8 °C

Summary: 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid, also known as 1,2,3,4-Tetrahydroquinoline-6-carboxylic acid, with CAS number 5382-49-0, molecular formula C10H11NO2, and molecular weight 177.200. For research-use only, not for medical or clinical usage.


 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.2±0.1 g/cm3
Boiling Point 382.6±31.0 °C at 760 mmHg
Melting Point 168ºC
Molecular Formula C10H11NO2
Molecular Weight 177.200
Flash Point 185.2±24.8 °C
Exact Mass 177.078979
PSA 49.33000
LogP 2.40
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.587
InChIKey ARNALYPZOYPNAF-UHFFFAOYSA-N
SMILES O=C(O)c1ccc2c(c1)CCCN2
Storage condition 2-8°C

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Name: 1 2 3 4-Tetrahydro-6-quinolinecarboxylic acid 97% Material Safety Data Sheet
Synonym:
CAS: 5382-49-0
Section 1 - Chemical Product MSDS Name:1 2 3 4-Tetrahydro-6-quinolinecarboxylic acid 97% Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
5382-49-0 1,2,3,4-Tetrahydro-6-quinolinecarboxyl 97% unlisted
Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 5382-49-0: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: beige
Odor: odorless - slight odor
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C10H11NO2
Molecular Weight: 177.2

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 5382-49-0 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
1,2,3,4-Tetrahydro-6-quinolinecarboxylic acid - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 5382-49-0: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 5382-49-0 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 5382-49-0 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
HS Code 2933499090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

~99%

1,2,3,4-Tetrahydroquinoline-6-carboxylic acid Structure

1,2,3,4-Tetrahy...

CAS#:5382-49-0

Learn More
Literature: Zhang, Cunyu; Westaway, Susan M.; Speake, Jason D.; Bishop, Michael J.; Goetz, Aaron S.; Carballo, Luz Helena; Hu, Mike; Epperly, Andrea H. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 2 p. 670 - 676

~61%

1,2,3,4-Tetrahydroquinoline-6-carboxylic acid Structure

1,2,3,4-Tetrahy...

CAS#:5382-49-0

Learn More
Literature: H. LUNDBECK A/S Patent: WO2005/39572 A1, 2005 ; Location in patent: Page/Page column 31-32 ;

~94%

1,2,3,4-Tetrahydroquinoline-6-carboxylic acid Structure

1,2,3,4-Tetrahy...

CAS#:5382-49-0

Learn More
Literature: Marchand, Pascal; Puget, Alain; Le Baut, Guillaume; Emig, Peter; Czech, Michael; Guenther, Eckhard Tetrahedron, 2005 , vol. 61, # 16 p. 4035 - 4041

~%

1,2,3,4-Tetrahydroquinoline-6-carboxylic acid Structure

1,2,3,4-Tetrahy...

CAS#:5382-49-0

Learn More
Literature: Tetrahedron, , vol. 61, # 16 p. 4035 - 4041

~%

1,2,3,4-Tetrahydroquinoline-6-carboxylic acid Structure

1,2,3,4-Tetrahy...

CAS#:5382-49-0

Learn More
Literature: Tetrahedron, , vol. 61, # 16 p. 4035 - 4041

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Bioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979
Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

1,2,3,4-TETRAHYDRO-6-QUINOLINECARBOXYLIC ACID
1,2,3,4-tetrahydroquinoline-6-carboxylic acid

  | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid?
A: Molecular formula of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid is C10H11NO2.
Q: What is the polar surface area (PSA) of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid?
A: Polar surface area (PSA) of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid is 49.33000.
Q: What are the downstream products of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid?
A: Related downstream products(CAS) of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid: 10349-57-2;177478-49-8;162648-46-6.
Q: What are the upstream materials of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid?
A: Related upstream materials(CAS) of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid: 10349-57-2;851202-94-3;50741-36-1;635-46-1;22190-35-8.
Q: What English synonyms does 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid have?
A: English synonyms of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid: 1,2,3,4-TETRAHYDRO-6-QUINOLINECARBOXYLIC ACID, 1,2,3,4-tetrahydroquinoline-6-carboxylic acid.
Q: What is the molecular weight of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid?
A: Molecular weight of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid is 177.200.
Q: What is the SMILES notation of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid?
A: SMILES notation of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid is O=C(O)c1ccc2c(c1)CCCN2.
Q: What is the InChIKey of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid?
A: InChIKey of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid is ARNALYPZOYPNAF-UHFFFAOYSA-N.
Q: What is the LogP of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid?
A: LogP of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid is 2.40.
Q: What is the English name of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid?
A: The English name of 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid is 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid.

 factory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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