Tetrahedron

Palladium (II)-catalyzed heterocyclisation of 8-arylethynyl-1, 2, 3, 4-tetrahydroquinolines: a facile route to 2-aryl-5, 6-dihydro-4H-pyrrolo [3, 2, 1-ij] quinoline derivatives

P Marchand, A Puget, G Le Baut, P Emig, M Czech…

Index: Marchand, Pascal; Puget, Alain; Le Baut, Guillaume; Emig, Peter; Czech, Michael; Guenther, Eckhard Tetrahedron, 2005 , vol. 61, # 16 p. 4035 - 4041

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Citation Number: 15

Abstract

Dihydropyrroloquinolines have been synthesized reacting 8-arylethynyl-1, 2, 3, 4- tetrahydroquinolines in the presence of palladium (II) chloride catalyst. Heteroannulation has been achieved in good yields and tolerates substituents on the tetrahydroquinoline, including bromo, cyano, and ester.