6-mercaptopurine riboside

Modify Date: 2026-07-13 19:09:39

6-mercaptopurine riboside Structure
6-mercaptopurine riboside structure
 Common Name 6-mercaptopurine riboside
CAS Number 574-25-4 Molecular Weight 284.29200
Density 2.02g/cm3 Boiling Point 714.7ºC at 760mmHg
Molecular Formula C10H12N4O4S Melting Point 220-223ºC(lit.)
MSDS N/A Flash Point 386ºC

 Use of 6-mercaptopurine riboside


6-​Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα[1][2].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 6-Mercaptopurine-9-D-riboside
Synonym More Synonyms

 6-mercaptopurine riboside Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description 6-​Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα[1][2].
Related Catalog
References

[1]. Lee J, et al. Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR gamma through JNK-dependent upregulation of iNOS. Cell Mol Life Sci. 2010 Feb;67(3):467-81.

[2]. Neubert D, et al. Interference of 6-mercaptopurine riboside, 6-methylmercaptopurine riboside and azathioprine with the morphogenetic differentiation of mouse extremities in vivo and in organ culture. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):93-105.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 2.02g/cm3
Boiling Point 714.7ºC at 760mmHg
Melting Point 220-223ºC(lit.)
Molecular Formula C10H12N4O4S
Molecular Weight 284.29200
Flash Point 386ºC
Exact Mass 284.05800
PSA 148.51000
Index of Refraction 1.6270 (estimate)
InChIKey NKGPJODWTZCHGF-KQYNXXCUSA-N
SMILES OCC1OC(n2cnc3c(=S)nc[nH]c32)C(O)C1O
Storage condition -20°C
Stability Store in Cool Dry Place

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UP0710000
CHEMICAL NAME :
9H-Purine-6-thiol, 9-beta-D-ribofuranosyl-
CAS REGISTRY NUMBER :
574-25-4
LAST UPDATED :
199606
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C10-H12-N4-O4-S
MOLECULAR WEIGHT :
284.32
WISWESSER LINE NOTATION :
T56 BN DN FN HNJ ISH D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1270 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1840 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
350 mg/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - skin and skin appendages Reproductive - Specific Developmental Abnormalities - homeostasis
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
175 mg/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
42 mg/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
87500 ug/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
21 mg/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - skin and skin appendages
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
42 mg/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
87500 ug/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - homeostasis

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
200 ug/plate
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 44,96,1985

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes Xn
Risk Phrases 22
Safety Phrases S22;S24/25
WGK Germany 3
RTECS UP0710000

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

EINECS 209-371-5
MFCD00005743

 6-mercaptopurine riboside | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the safety information for 6-Mercaptopurine-9-D-riboside?
A: Safety information for 6-Mercaptopurine-9-D-riboside: S22;S24/25.
Q: What are the upstream materials of 6-Mercaptopurine-9-D-riboside?
A: Related upstream materials(CAS) of 6-Mercaptopurine-9-D-riboside: 157930-09-1;58-96-8;108321-99-9;3021-21-4;1146104-45-1;67-56-1;38048-32-7;107-03-9.
Q: What is the InChIKey of 6-Mercaptopurine-9-D-riboside?
A: InChIKey of 6-Mercaptopurine-9-D-riboside is NKGPJODWTZCHGF-KQYNXXCUSA-N.
Q: What is the boiling point of 6-Mercaptopurine-9-D-riboside?
A: Boiling point of 6-Mercaptopurine-9-D-riboside is 714.7ºC at 760mmHg.
Q: What is the molecular weight of 6-Mercaptopurine-9-D-riboside?
A: Molecular weight of 6-Mercaptopurine-9-D-riboside is 284.29200.
Q: What is the CAS number of 6-Mercaptopurine-9-D-riboside?
A: CAS number of 6-Mercaptopurine-9-D-riboside is 574-25-4.
Q: What are the storage conditions for 6-Mercaptopurine-9-D-riboside?
A: Storage conditions for 6-Mercaptopurine-9-D-riboside: -20°C.
Q: What English synonyms does 6-Mercaptopurine-9-D-riboside have?
A: English synonyms of 6-Mercaptopurine-9-D-riboside: EINECS 209-371-5, MFCD00005743.
Q: What is the polar surface area (PSA) of 6-Mercaptopurine-9-D-riboside?
A: Polar surface area (PSA) of 6-Mercaptopurine-9-D-riboside is 148.51000.
Q: What are the uses of 6-Mercaptopurine-9-D-riboside?
A: Main uses of 6-Mercaptopurine-9-D-riboside: 6-​Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα[1][2].

 6-mercaptopurine ribosidefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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